ArticleMicrobial pathogenesis2010
Unraveling the mechanism of action of a new type III secretion system effector AexU from Aeromonas hydrophila.
Article in Microbial pathogenesis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Pathogenicity and virulence of Aeromonas schubertii in farmed Asian seabass (Lates calcarifer) in Thailand.BMC veterinary research · 2025Article
- Cytotoxicity induced by Aeromonas schubertii is orchestrated by a unique set of type III secretion system effectors.Veterinary research · 2025Article
- Clinical Presentation, Antimicrobial Resistance, and Treatment Outcomes of Aeromonas Human Infections: A 14-Year Retrospective Study and Comparative Genomics of 2 Isolates From Fatal Cases.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Emergence and clonal expansion of Aeromonas hydrophila ST1172 that simultaneously produces MOX-13 and OXA-724.Antimicrobial resistance and infection control · 2024Article
- Heterologous Assembly of the Type VI Secretion System Empowers Laboratory Escherichia coli with Antimicrobial and Cell Penetration Capabilities.Applied and environmental microbiology · 2022Article
- Categorizing Sequences of Concern by Function To Better Assess Mechanisms of Microbial Pathogenesis.Infection and immunity · 2022Review
- Comparative genomics analysis of the multidrug-resistantFrontiers in cellular and infection microbiology · 2022Article
- Delivering the pain: an overview of the type III secretion system with special consideration for aquatic pathogens.Veterinary research · 2021Review
- Pancreaticobiliary Cancers and Aeromonas Isolates Carrying Type Ⅲ Secretion System GenesFrontiers in cellular and infection microbiology · 2021Article
- Comparative and Evolutionary Genomics of Isolates Provide Insight into the Pathoadaptation of Aeromonas.Genome biology and evolution · 2020Article
- An Update on the GenusMicroorganisms · 2020Review
- The Significance of MesophilicMicroorganisms · 2019Review
- Bacteriological, Clinical and Virulence Aspects of Aeromonas-associated Diseases in Humans.Polish journal of microbiology · 2018Review
- The Outer Membrane Vesicles ofFrontiers in microbiology · 2018Article
- Article
- Virulence Factors of Aeromonas hydrophila: In the Wake of Reclassification.Frontiers in microbiology · 2016Review
- Functional genomic characterization of virulence factors from necrotizing fasciitis-causing strains of Aeromonas hydrophila.Applied and environmental microbiology · 2014Article
- Evaluation of the roles played by Hcp and VgrG type 6 secretion system effectors in Aeromonas hydrophila SSU pathogenesis.Microbiology (Reading, England) · 2013Article
- Article
- Modulation of host immune defenses by Aeromonas and Yersinia species: convergence on toxins secreted by various secretion systems.Frontiers in cellular and infection microbiology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We recently characterized a T3SS effector, AexU, from a diarrheal isolate SSU of Aeromonas hydrophila, which exhibited ADP-ribosyltransferase (ADPRT) activity. Here we provided evidence that AexU also possessed GTPase-activating protein (GAP) activity, which was mainly responsible for host cell apoptosis and disruption of actin filaments. Earlier, we showed that the DeltaaexU null mutant was attenuated in a mouse model, and we now demonstrated that while the parental A. hydrophila strain could be detected in the lung, liver, and spleen of infected mice, the DeltaaexU mutant was rapidly cleared from these organs resulting in increased survivability of animals. Further, AexU prevented phosphorylation of c-Jun, JNK and IkappaBalpha and inhibited IL-6 and IL-8 secretion from HeLa cells. Our data indicated that AexU operated by inhibiting NF-kappaB and inactivating Rho GTPases. Importantly, however, when the DeltaaexU null mutant was complemented with the mutated aexU gene devoid of ADPRT and GAP activities, a higher mortality rate in mice with concomitant increase in the production of pro-inflammatory cytokines/chemokines was noted. These data indicated that either such a mutated AexU is a potent inducer of them or that AexU possesses yet another unknown activity that is modulated by ADPRT and GAP activities and results in this aberrant cytokine/chemokine production responsible for increased animal death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.