Underpowered trials in critical care medicine: how to deal with them?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

4 citing papers in PubMed.

1. Covariate adjustment increased power in randomized controlled trials: an example in traumatic brain injury.Journal of clinical epidemiology · 2012
   Trial
2. AI-enabled clinical trials.Nature reviews bioengineering · 2026
   Article
3. Effects of intense assessment on statistical power in randomized controlled trials: Simulation study on depression.Internet interventions · 2020
   Article
4. Outcomes and statistical power in adult critical care randomized trials.American journal of respiratory and critical care medicine · 2014
   Article

Corrections and comments

• Comment on
  Delta inflation: a bias in the design of randomized controlled trials in critical care medicine.2010

Authors and funding

5 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as