ArticleJournal of experimental & clinical cancer research : CR2010
Association of interleukin-10 gene polymorphisms with breast cancer in a Chinese population.
Article in Journal of experimental & clinical cancer research : CR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 8 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 8 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Association of Interleukin-10 Polymorphism (rs1800896, rs1800871, and rs1800872) With Breast Cancer Risk: An Updated Meta-Analysis Based on Different Ethnic Groups.Frontiers in genetics · 2022Pooled it
- The single nucleotide polymorphisms of interleukin-10 are associated with the risk of leukaemia: Evidence from 18 case-control studies.Medicine · 2020Pooled it
- Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis.The Journal of international medical research · 2020Pooled it
- Association of IL-10 rs1800871 and rs1800872 Polymorphisms with Breast Cancer Risk: A Systematic Review and Meta-AnalysisAsian Pacific journal of cancer prevention : APJCP · 2018Pooled it
- The interleukin 10 -819C/T polymorphism and cancer risk: a HuGE review and meta-analysis of 73 studies including 15,942 cases and 22,336 controls.Omics : a journal of integrative biology · 2013Pooled it
- Pooled it
- The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.Familial cancer · 2012Pooled it
- Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility: a meta-analysis.World journal of gastroenterology · 2011Pooled it
- IL-10 Polymorphism and Breast Cancer Risk in Georgian Women: A Case-Control Study.Global medical genetics · 2023Article
- Corneal Healing and Recovery of Ocular Crystallinity with a Dichloromethane Extract ofMolecules (Basel, Switzerland) · 2021Article
- A Survey on the Role of Interleukin-10 in Breast Cancer: A Narrative.Reports of biochemistry & molecular biology · 2018Article
- Association of three promoter polymorphisms in interleukin-10 gene with cancer susceptibility in the Chinese population: a meta-analysis.Oncotarget · 2017Article
- Constitutive activation of STAT3 in breast cancer cells: A review.International journal of cancer · 2016Review
- A pooled analysis of the IL-10-1082 A/G polymorphism and the nasopharyngeal carcinoma susceptibility.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Review
- ACC interleukin-10 gene promoter haplotype as a breast cancer risk factor predictor among Jordanian females.OncoTargets and therapy · 2016Article
- A Common SNP of IL-10 (-1082A/G) is Associated With Increased Risk of Premenopausal Breast Cancer in South Indian Women.Iranian journal of cancer prevention · 2015Article
- The prognostic value of IL10 and TNF alpha functional polymorphisms in premenopausal early-stage breast cancer patients.BMC genetics · 2015Article
- Single Nucleotide Polymorphisms in IL-10, IL-12p40, and IL-13 Genes and Susceptibility to Glioma.International journal of medical sciences · 2015Article
- Genetic polymorphisms in inflammatory response genes and their associations with breast cancer risk.Croatian medical journal · 2014Article
- Interleukin-10 genotype correlated to deficiency syndrome in hepatitis B cirrhosis.Evidence-based complementary and alternative medicine : eCAM · 2012Article
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterleukin-10(IL-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenic functions. Polymorphisms in the IL-10 gene promoter genetically determine interindividual differences in IL-10 production. This study was performed to determined whether polymorphisms in the IL-10 gene promoter were associated with breast cancer in a Chinese Han population.
methodsWe genotyped 315 patients with breast cancer and 322 healthy control subjects for -1082A/G, -819T/C and -592A/C single nucleotide polymorphisms in the promoter region of the IL-10 gene by polymerase chain reactionerestriction fragment length polymorphism (PCR-RFLP).
resultsThere were no significant differences in genotype, allele, or haplotype frequencies in all three loci between patients and healthy controls. Analysis of breast cancer prognostic and predictive factors revealed that the -1082AA genotype was associated with a significantly increased risk of lymph node (LN) involvement (P = 0.041) and larger tumor size (P = 0.039) at the time of diagnosis. Furthermore, in the haplotype analysis of IL-10 gene, we found that patients carrying ATA haplotype were in higher LN involvement (p = 0.022) and higher tumor stage(p = 0.028) of breast cancer at the time of diagnosis compared with others.
conclusionsOur findings suggest that IL-10 promoter polymorphisms participate in the progression of breast cancer rather than in its initial development in Chinese Han women.
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