ArticleThe FEBS journal2010
An autoinhibitory effect of the homothorax domain of Meis2.
Article in The FEBS journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- OsIDD7 integrates signaling networks for arbuscular mycorrhizal symbiosis.Nature communications · 2026Article
- Meis1 isoform diversity orchestrates neural progenitor differentiation by regulating ATOH1 degradation at distinct subcellular compartments.PLoS biology · 2026Article
- OGT mediates O-GlcNAcylation of MEIS2 and affects palatal osteogenic development.International journal of oral science · 2026Article
- RLS-associated MEIS transcription factors control distinct processes in human neural stem cells.Scientific reports · 2024Article
- The neuronal transcription factor MEIS2 is a calpain-2 protease target.Journal of cell science · 2024Article
- HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation.PLoS genetics · 2020Article
- Article
- TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.Genes & development · 2019Article
- Hippo Signaling in Cancer: Lessons FromFrontiers in cell and developmental biology · 2019Review
- Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression.Biochimica et biophysica acta. Gene regulatory mechanisms · 2018Article
- Article
- Depletion of MEIS2 inhibits osteogenic differentiation potential of human dental stem cells.International journal of clinical and experimental medicine · 2015Article
- MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression.Cell death & disease · 2014Article
- Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development.BMC developmental biology · 2012Article
- Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.Molecular and cellular biology · 2011Article
- Contrasting 5' and 3' evolutionary histories and frequent evolutionary convergence in Meis/hth gene structures.Genome biology and evolution · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Myeloid ecotropic insertion site (Meis)2 is a homeodomain protein containing a conserved homothorax (Hth) domain that is present in all Meis and Prep family proteins and in the Drosophila Hth protein. The Hth domain mediates interaction with Pbx homeodomain proteins, allowing for efficient DNA binding. Here we show that, like Meis1, Meis2 has a strong C-terminal transcriptional activation domain, which is required for full activation of transcription by homeodomain protein complexes composed of Meis2 and Pbx1. We also show that the activity of the activation domain is inhibited by the Hth domain, and that this autoinhibition can be partially relieved by the interaction of Pbx1 with the Hth domain of Meis2. Targeting of the Hth domain to DNA suggests that it is not a portable trans-acting repression domain. However, the Hth domain can inhibit a linked activation domain, and this inhibition is not limited to the Meis2 activation domain. Database searching reveals that the Meis3.2 splice variant, which is found in several vertebrate species, disrupts the Hth domain by removing 17 codons from the 5'-end of exon 6. We show that the equivalent deletion in Meis2 derepresses the C-terminal activation domain and weakens interaction with Pbx1. This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.