ArticleDrug safety2010
Enhancing pharmacosurveillance with systematic collection of treatment indication in electronic prescribing: a validation study in Canada.
Article in Drug safety, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Indication documentation and indication-based prescribing within electronic prescribing systems: a systematic review and narrative synthesis.BMJ quality & safety · 2023Pooled it
- Prescription duration of benzodiazepines: a retrospective cohort study of prescription duration in primary care.European journal of clinical pharmacology · 2026Article
- Off-Label Prescription of Benzodiazepines: A Retrospective Cohort Study of Prescribing Prevalence in Primary Care.Clinical drug investigation · 2025Article
- Effectiveness and safety of apixaban and rivaroxabanWorld journal of nephrology · 2023Article
- Article
- Trends of use and factors that determine the choice of oral anticoagulants in women and men with atrial fibrillation.Pharmacology research & perspectives · 2022Article
- Indication alerts to improve problem list documentation.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- Comparative Effectiveness and Safety of Direct Oral Anticoagulants vs Warfarin Among Obese Patients With Atrial Fibrillation.CJC open · 2022Article
- Effectiveness and safety of low-dose versus standard-dose rivaroxaban and apixaban in patients with atrial fibrillation.PloS one · 2022Article
- Including the Reason for Use on Prescriptions Sent to Pharmacists: Scoping Review.JMIR human factors · 2021Article
- Predicting major bleeding among hospitalized patients using oral anticoagulants for atrial fibrillation after discharge.PloS one · 2021Article
- Comparative Effectiveness and Safety of Low-Dose Oral Anticoagulants in Patients With Atrial Fibrillation.Frontiers in pharmacology · 2021Article
- Development of the prototype concise safe systems checklist tool for general practice.BMC health services research · 2020Article
- Can Hyperparameter Tuning Improve the Performance of a Super Learner?: A Case Study.Epidemiology (Cambridge, Mass.) · 2019Article
- Article
- Comparison of a Prototype for Indications-Based Prescribing With 2 Commercial Prescribing Systems.JAMA network open · 2019Article
- New approaches to pharmacosurveillance for monitoring prescription frequency, diversity, and co-prescription in a large sentinel network of companion animal veterinary practices in the United Kingdom, 2014-2016.Preventive veterinary medicine · 2018Article
- Using electronic health records to characterize prescription patterns: focus on antidepressants in nonpsychiatric outpatient settings.JAMIA open · 2018Article
- Assessing the accuracy of using diagnostic codes from administrative data to infer antidepressant treatment indications: a validation study.Pharmacoepidemiology and drug safety · 2018Article
- Derivation and validation of a multivariable model to predict when primary care physicians prescribe antidepressants for indications other than depression.Clinical epidemiology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundAdverse drug reaction reports used in pharmacosurveillance often lack complete information on treatment indication that is important for benefit-risk analyses and clinical and regulatory decision making. A systematic documentation of treatment indication using electronic prescribing applications provides an opportunity to develop new pharmacosurveillance tools that will allow evaluation of drugs by weighing benefits and risks for specific indications, and evaluate off-label prescribing. In addition, interfacing indications with reminders and clinical guidelines can enhance clinical decision making. We investigated the validity of treatment indications documented using an electronic prescribing system at the time of prescribing.
objectivesTo determine the sensitivity and positive predictive value (PPV) of an electronic prescribing system in documenting treatment indications at the time of drug prescribing, and to investigate the use of treatment indication data to evaluate off-label prescribing in primary-care practice. STUDY DESIGN AND
settingWe prospectively assessed the validity of documenting treatment indication using an electronic prescribing system by comparing it with treatment indications documented by physician-facilitated medical chart review ('gold standard'). Sensitivity and PPV were evaluated in 338 patients of 22 community-based primary-care physicians in Quebec, Canada, in 2006.
resultsThe sensitivity of the electronic prescribing system in documenting treatment indication was 98.5% (95% CI 96.5, 99.5) and the PPV of the system in accurately identifying the treatment indication was 97.0% (95% CI 94.2, 98.6). The treatment indication data collected using this system allowed assessment of off-label prescribing.
conclusionsThe electronic prescribing system offers a valid method for documenting treatment indication at the time of prescribing. Our results provide strong evidence to support incorporating mandatory recording of treatment indication in integrated electronic prescribing systems to provide a critical piece of information for the evaluation of safety and effectiveness of drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.