ArticleMethods in molecular biology (Clifton, N.J.)2010
Visualization of retinoid storage and trafficking by two-photon microscopy.
Article in Methods in molecular biology (Clifton, N.J.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation.Progress in retinal and eye research · 2023Review
- Two-photon excitation fluorescence in ophthalmology: safety and improved imaging for functional diagnostics.Frontiers in medicine · 2023Review
- Stability of retinol in liposomes as measured by fluorescence lifetime spectroscopy and FLIM.BBA advances · 2023Article
- Structure and dynamics of photoreceptor sensory cilia.Pflugers Archiv : European journal of physiology · 2021Review
- Characterization of Retinol Stabilized in Phosphatidylcholine Vesicles with and without Antioxidants.ACS omega · 2020Article
- The role of the retinoids in schizophrenia: genomic and clinical perspectives.Molecular psychiatry · 2020Review
- Endogenous fluorophores enable two-photon imaging of the primate eye.Investigative ophthalmology & visual science · 2014Article
- Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Chemistry of the retinoid (visual) cycle.Chemical reviews · 2014Review
- Coherent anti-stokes Raman scattering (CARS) microscopy: a novel technique for imaging the retina.Investigative ophthalmology & visual science · 2013Article
- Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues.The Journal of biological chemistry · 2011Article
- Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes.Nature medicine · 2010Article
- Retinoids for treatment of retinal diseases.Trends in pharmacological sciences · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vertebrate vision is maintained by the retinoid (visual) cycle, a complex enzymatic pathway that operates in the retina to regenerate the visual chromophore, 11-cis-retinal, a prosthetic group of rhodopsin that undergoes activation by light. Many different mutations in genes encoding retinoid cycle proteins can cause a variety of human blinding diseases. Two-photon microscopy is an evolving, non-invasive, and repetitive imaging technology that can be used to monitor biomolecules within the vertebrate retina at a subcellular resolution. This method has the great advantage of portraying endogenous retinoid fluorophores in their native state without the need for artificial staining. Such real-time retinal imaging permits rapid evaluation not only of various stages of retinal disease in live animal models of human retinopathies but also of the outcome from intended pharmacological therapies. Two-photon microscopy offers substantial potential for early detection of age- and disease-related changes in the eye, long before clinical or pathological manifestations become apparent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.