ReviewSurgical endoscopy2011
Peritoneal changes due to laparoscopic surgery.
Review in Surgical endoscopy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03330067 (Warm and Humidified vs Cold and Dry Dry Carbon Dioxide), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Warm and Humidified vs Cold and Dry Dry Carbon Dioxide (CO2) Pneumoperitoneum in Minimally Invasive Colorectal Resection: A Randomized Controlled Trial and Study of Clinical Endpoints
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Clinical Outcomes after the Use of Antiadhesive Agents in Laparoscopic Reproductive Surgery.Gynecologic and obstetric investigation · 2023Pooled it
- Low intra-abdominal pressure and deep neuromuscular blockade laparoscopic surgery and surgical space conditions: A meta-analysis.Medicine · 2020Pooled it
- Trial
- Biomolecular inflammatory response to surgical energy usage in laparoscopic surgery: results of a randomized study.Surgical endoscopy · 2016Trial
- Insufflation with humidified and heated carbon dioxide in short-term laparoscopy: a double-blinded randomized controlled trial.BioMed research international · 2015Trial
- Variations of nociception level (NOLBMC anesthesiology · 2025Article
- Impact of Low- Versus Standard-Pressure Pneumoperitoneum on Postoperative Recovery in Patients with Obesity Undergoing Robot-Assisted Radical Prostatectomy: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
- Effects of intraperitoneal magnesium sulfate on perioperative inflammatory response in rats with pneumoperitoneum.BMC anesthesiology · 2025Article
- Induction of Endometriosis in a Menstruating Mouse Model (Mus musculus): A Translational Animal Disease Model.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- The Simultaneous Deletion of pH-Sensing Receptors GPR4 and OGR1 (GPR68) Ameliorates Colitis with Additive Effects on Multiple Parameters of Inflammation.International journal of molecular sciences · 2025Article
- Role of pH-sensing receptors in colitis.Pflugers Archiv : European journal of physiology · 2024Review
- Moderate Intra-Abdominal Pressure Levels in Robot-Assisted Radical Prostatectomy Seem to Have No Negative Impact on Clinical Outcomes.Journal of clinical medicine · 2024Article
- Intestinal Anastomotic Healing: What do We Know About Processes Behind Anastomotic Complications.Frontiers in surgery · 2022Review
- Effects of Heated Pneumoperitoneum on Inflammation, Oxidative Stress, and Peritoneal Histology in Female Dogs That Underwent Video-Assisted Ovariohysterectomy.Veterinary medicine international · 2021Article
- Comparison of Deep and Moderate Neuromuscular Blockade on Intestinal Mucosal Barrier in Laparoscopic Gastrectomy: A Prospective, Randomized, Double-Blind Clinical Trial.Frontiers in medicine · 2021Article
- Deep Neuromuscular Blockade Combined with Low Pneumoperitoneum Pressure for Nociceptive Recovery After Major Laparoscopic Gastrointestinal Surgery: Study Protocol for a Randomized Controlled Trial.Journal of pain research · 2021Article
- Retroperitoneoscopic nephroureterectomy and ipsilateral bladder cuff resection in peritoneal dialysis-dependent patients: tips for immediate reinstitution.International urology and nephrology · 2020Article
- Modes of carbon dioxide delivery during laparoscopy generate distinct differences in peritoneal damage and hypoxia in a porcine model.Surgical endoscopy · 2020Article
- Iodine overlays to improve differentiation between peritoneal carcinomatosis and benign peritoneal lesions.European radiology · 2020Article
- Selection criteria and colpotomic approach for safe minimally invasive radical hysterectomy in early-stage cervical cancer.Journal of gynecologic oncology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLaparoscopic surgery has been incorporated into common surgical practice. The peritoneum is an organ with various biologic functions that may be affected in different ways by laparoscopic and open techniques. Clinically, these alterations may be important in issues such as peritoneal metastasis and adhesion formation.
methodsA literature search using the Pubmed and Cochrane databases identified articles focusing on the key issues of laparoscopy, peritoneum, inflammation, morphology, immunology, and fibrinolysis.
resultsLaparoscopic surgery induces alterations in the peritoneal integrity and causes local acidosis, probably due to peritoneal hypoxia. The local immune system and inflammation are modulated by a pneumoperitoneum. Additionally, the peritoneal plasmin system is inhibited, leading to peritoneal hypofibrinolysis.
conclusionSimilar to open surgery, laparoscopic surgery affects both the integrity and biology of the peritoneum. These observations may have implications for various clinical conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.