ArticleMolecular imaging and biology2011
Influence of glioma's multidrug resistance phenotype on (99m)Tc-tetrofosmin uptake.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Haloperidol Induced Cell Cycle Arrest and Apoptosis in Glioblastoma Cells.Biomedicines · 2020Article
- Comparison of (99m)tc-tetrofosmin and (99m)tc-sestamibi uptake in glioma cell lines: the role of p-glycoprotein expression.International journal of molecular imaging · 2014Article
- Combined QSAR and molecule docking studies on predicting P-glycoprotein inhibitors.Journal of computer-aided molecular design · 2013Article
- The role of 99mTc-tetrofosmin brain SPECT in differentiating treatment-induced necrosis from recurrent brain tumor.Journal of neuro-oncology · 2011Article
- 99mTc-tetrofosmin SPECT for the evaluation of cerebral lesions.European journal of nuclear medicine and molecular imaging · 2010Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMultidrug resistance (MDR) remains a major obstacle to successful chemotherapeutic treatment of cancer. Several chemotherapeutic and radiopharmaceutical agents are substrates of the pumps encoded by the MDR genes, and therefore, their accumulation is prevented. We evaluated in vivo whether [(99m)Tc]tetrofosmin ((99m)Tc-TF) uptake is influenced by the MDR profile of gliomas. PROCEDURES: Eighteen patients with histologically confirmed glioma were included in the study. Brain single-photon emission computed tomography by (99m)Tc-TF was performed within a week prior to surgical excision, and the expression of MRP5 was assessed by immunohistochemistry. Radiotracer accumulation was assessed by a semiquantitative method, calculating the lesion-to-normal uptake ratio.
resultsUsing Spearman's ρ analysis, we found no correlation between tracer uptake expressed as lesion-to-normal and MRP5 expression. There was a significant correlation between glioma aggressiveness as assessed by Ki-67/MIB-1 and MRP5 expression.
conclusionThe present data suggest that (99m)Tc-TF uptake is not influenced by glioma's MDR phenotype. Thus, (99m)Tc-TF constitutes a suitable radiotracer for imaging gliomas.
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