ArticleMycopathologia2010
Pathogenesis of pulmonary Cryptococcus gattii infection: a rat model.
Article in Mycopathologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Quantitative MRI of a Cerebral Cryptococcoma Mouse Model for In Vivo Distinction between Different Cryptococcal Molecular Types.Journal of fungi (Basel, Switzerland) · 2024Article
- Preclinical Models for Cryptococcosis of the CNS and Their Characterization Using In Vivo Imaging Techniques.Journal of fungi (Basel, Switzerland) · 2024Review
- Models for Inducing Experimental Cryptococcosis in Mice.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Cryptococcus spp. and Cryptococcosis: focusing on the infection in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Review
- A Possible Link between the Environment andInternational journal of environmental research and public health · 2022Article
- The aetiology and clinical characteristics of cryptococcal infections in Far North Queensland, tropical Australia.PloS one · 2022Article
- Reimagining the future of African brain health: Perspectives for basic research on the pathogenesis of cryptococcal meningitis.Brain, behavior, & immunity - health · 2021Article
- Rearing and Maintenance ofJournal of fungi (Basel, Switzerland) · 2020Review
- Animal Models ofFrontiers in immunology · 2020Review
- Clonal Dispersal ofJournal of fungi (Basel, Switzerland) · 2019Article
- Cryptococcus gattii Infection Presenting as an Aggressive Lung Mass.Mycopathologia · 2018Article
- Genotypic and Phenotypic Diversity ofFrontiers in microbiology · 2018Article
- Cryptococcus neoformans var. grubii-Induced Arthritis with Encephalitic Dissemination in a Dog and Review of Published Literature.Mycopathologia · 2016Review
- Yeasts Associated with Culex pipiens and Culex theileri Mosquito Larvae and the Effect of Selected Yeast Strains on the Ontogeny of Culex pipiens.Microbial ecology · 2016Article
- Cryptococcosis.Infectious disease clinics of North America · 2016Review
- Cryptococcus gattii infections.Clinical microbiology reviews · 2014Review
- Galleria mellonella model identifies highly virulent strains among all major molecular types of Cryptococcus gattii.PloS one · 2014Article
- A murine model of Cryptococcus gattii meningoencephalitis.The Journal of antimicrobial chemotherapy · 2012Article
- Cryptococcus gattii comparative genomics and transcriptomics: a NIH/NIAID White Paper.Mycopathologia · 2012Review
- Experimental models of cryptococcosis.International journal of microbiology · 2012Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A model of pulmonary cryptococcosis in immunocompetent rats was developed to better understand the virulence of Cryptococcus gattii. Six isolates were studied, representing four molecular genotypes (VGI-MATα, VGIIa-MATα, VGIIa-MAT a, VGIIb-MATα), obtained from Australia, Vancouver (Canada) and Colombia. These originated from human patients, a cat and the environment and were administered intratracheally (i.t.) or transthoracically into Fischer 344 or Wistar-Furth rats in doses varying from 10(4) to 10(7) colony-forming units (CFU) in 0.1 ml of saline. With the exception of animals given the VGIIa-MAT a isolate, rats consistently became ill or died of progressive cryptococcal pneumonia following i.t. doses exceeding 10(7) CFU. Affected lungs increased in weight up to tenfold and contained numerous circumscribed, gelatinous lesions. These became larger and more extensive, progressing from limited hilar and/or tracheal lesions, to virtually confluent gelatinous masses. Disease was localized to the lungs for at least 3-4 weeks, with dissemination to the brain occurring in some animals after day 29. The dose-response relationship was steep for two VGI isolates studied (human WM179, environmental WM276); doses up to 10(6) CFU i.t. did not produce lesions, while 10(7) or more yeast cells produced progressive pneumonia. Intratracheal inoculation of rats with C. gattii provides an excellent model of human pulmonary cryptococcosis in healthy hosts, mimicking natural infections. Disease produced by C. gattii in rats is distinct from that caused by C. neoformans in that infections are progressive and ultimately fatal.
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