ReviewBehavior genetics2010
The complexity of alcohol drinking: studies in rodent genetic models.
Review in Behavior genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 113 citations in OpenAlex.
- N-methyl-D-aspartate receptor antagonism has differential effects on alcohol craving and drinking in heavy drinkers.Alcoholism, clinical and experimental research · 2015Trial
- Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study.Biological psychiatry · 2014Trial
- Behavioral economic demand for ethanol in Long Evans rats: Influence of choice context, sex, and vapor history.Psychopharmacology · 2026Article
- Initial Drug Sensitivity and Vulnerability to Substance Use Disorders: A Review of Individual Influences.Biology · 2026Review
- Effect of low-intensity focused ultrasound on hippocampus of alcohol addicted mice: a preliminary study.Frontiers in neuroscience · 2026Article
- Morphine and nicotine intake in high drinking in the dark mice is reduced by informatics-nominated and translationally relevant compounds.Frontiers in psychiatry · 2026Article
- Epigenetic Dysregulation in Alcohol-Associated Behaviors: Preclinical and Clinical Evidence.Current topics in behavioral neurosciences · 2025Review
- Modeling Brain Gene Expression in Alcohol Use Disorder with Genetic Animal Models.Current topics in behavioral neurosciences · 2025Review
- Animal Models of Excessive Alcohol Consumption in Rodents.Current topics in behavioral neurosciences · 2025Review
- Chronic alcohol consumption shifts learning strategies and synaptic plasticity from hippocampus to striatum-dependent pathways.Frontiers in psychiatry · 2023Article
- Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways.Psychopharmacology · 2022Review
- From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self-administration in male rats.Addiction biology · 2022Article
- Increased Voluntary Alcohol Consumption in Mice Lacking GABAFrontiers in behavioral neuroscience · 2022Article
- Reduction of Cell Proliferation by Acute CCancers · 2021Article
- The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice.Alcohol (Fayetteville, N.Y.) · 2021Article
- Genetically selected alcohol-preferring msP rats to study alcohol use disorder: Anything lost in translation?Neuropharmacology · 2021Review
- On the Use of Heterogeneous Stock Mice to Map Transcriptomes Associated With Excessive Ethanol Consumption.Frontiers in psychiatry · 2021Review
- Voluntary alcohol consumption is increased in female, but not male, oxytocin receptor knockout mice.Brain and behavior · 2020Article
- Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations.Advances in pharmacology (San Diego, Calif.) · 2020Review
- Rigor and reproducibility in rodent behavioral research.Neurobiology of learning and memory · 2019Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Risk for alcohol dependence in humans has substantial genetic contributions. Successful rodent models generally attempt to address only selected features of the human diagnosis. Most such models target the phenotype of oral administration of alcohol solutions, usually consumption of or preference for an alcohol solution versus water. Data from rats and mice for more than 50 years have shown genetic influences on preference drinking and related phenotypes. This paper summarizes some key findings from that extensive literature. Much has been learned, including the genomic location and possible identity of several genes influencing preference drinking. We report new information from congenic lines confirming QTLs for drinking on mouse chromosomes 2 and 9. There are many strengths of the various phenotypic assays used to study drinking, but there are also some weaknesses. One major weakness, the lack of drinking excessively enough to become intoxicated, has recently been addressed with a new genetic animal model, mouse lines selectively bred for their high and intoxicating blood alcohol levels after a limited period of drinking in the circadian dark. We report here results from a second replicate of that selection and compare them with the first replicate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.