ArticleJournal of cancer research and clinical oncology2011
Evaluating mitochondrial DNA in patients with breast cancer and benign breast disease.
Article in Journal of cancer research and clinical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Evaluation of non-coding region sequence variants and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in individuals of Sri Lankan Sinhalese ethnicity.Biomedical reports · 2020Article
- Mitochondria in cancer.Cell stress · 2020Review
- The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma.Clinical epigenetics · 2018Article
- Article
- Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma.Oncology letters · 2018Article
- Mitochondrial DNA haplotypes induce differential patterns of DNA methylation that result in differential chromosomal gene expression patterns.Cell death discovery · 2017Article
- The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities.Frontiers in oncology · 2017Review
- Antibody Therapeutics in Oncology.Immunotherapy (Los Angeles, Calif.) · 2016Article
- Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry.Circulation. Cardiovascular genetics · 2016Article
- Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress.Mitochondrion · 2016Article
- Screening of mitochondrial mutations and insertion-deletion polymorphism in gestational diabetes mellitus in the Asian Indian population.Saudi journal of biological sciences · 2015Article
- Mutational patterns in the breast cancer mitochondrial genome, with clinical correlates.Carcinogenesis · 2014Article
- Mitochondrial DNA mutations and breast tumorigenesis.Biochimica et biophysica acta · 2013Review
- Mitochondria and familial predisposition to breast cancer.Current genomics · 2013Article
- Impaired mitochondrial metabolism and mammary carcinogenesis.Journal of mammary gland biology and neoplasia · 2013Review
- Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.The Journal of clinical investigation · 2013Article
- Review
- Physiology and pathophysiology of mitochondrial DNA.Advances in experimental medicine and biology · 2012Review
- The role of the mitochondrial genome in ageing and carcinogenesis.Journal of aging research · 2011Article
- The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer.BMC medical genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo evaluate the role of mtDNA in breast cancer.
methodsWe carried out an investigation into the mtDNA major control region or D-loop region and an essential and the largest mtDNA protein-coding gene, NADH dehydrogenase subunit 5 (ND5), together with a mitochondrial haplogroup analysis in 64 patients with breast cancer (BC) and 54 patients with benign breast disease (BBD) as controls.
resultsMutations in D-loop region were found in 10/64 or 15.6% of patients with BC and 14/54 or 25.9% of patients with BBD, while mutations in ND5 were detected in 6/64 or 9.4% of patients with BC and 5/54 or 9.3% of patients with BBD. In addition, in patients with BBD, mtDNA mutations were more likely to rise in D-loop region and the mutations were more likely to be heteroplasmic. However, in patients with BC, those with metastatic feature were less likely to carry mutations in D-loop region. Finally, we found haplogroup M has an increased risk of breast cancer compared with haplogroup N.
conclusionmtDNA mutation may play a role in early stage of tumorigenesis, and mitochondrial haplogroup can also modulate breast cancer occurrence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.