ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2010
Surgery for hydrocephalus in sub-Saharan Africa versus developed nations: a risk-adjusted comparison of outcome.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Efficacy and safety of endoscopic third ventriculostomy and choroid plexus cauterization for infantile hydrocephalus: a systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Pooled it
- Quantitative ventricular volume changes after endoscopic third ventriculostomy in children with Dandy-Walker malformation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- The top 100 most cited peer-reviewed publications on global neurosurgery: Mapping research trends and gaps over four decades.Acta neurochirurgica · 2026Review
- Pediatric hydrocephalus in Nigeria: a scoping review of management, treatment outcomes, and challenges.Neurosurgical review · 2026Article
- Treatments for obstructive hydrocephalus secondary to malignant midline intracranial tumors during the perioperative period - a retrospective study of 372 pediatric patients from a single institution.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Current Trends in the Treatment of Pediatric Hydrocephalus: A Narrative Review Centered on the Indications, Safety, Efficacy, and Long-Term Outcomes of Available Treatment Modalities.Children (Basel, Switzerland) · 2024Review
- Ventriculoperitoneal shunt failures at Red Cross War Memorial Children's Hospital.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Development of shunt valves used for treating hydrocephalus: comparison with endoscopy treatment.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Failure of Endoscopic Third Ventriculostomy.Cureus · 2022Review
- Endoscopic third ventriculostomy versus ventriculoperitoneal shunt insertion for the management of pediatric hydrocephalus in African centers - A systematic review and meta-analysis.Surgical neurology international · 2022Review
- Endoscopic third ventriculostomy and choroid plexus cauterization (ETV/CPC) for hydrocephalus of infancy: a technical review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Global Surgery Indicators and Pediatric Hydrocephalus: A Multicenter Cross-Country Comparative Study Building the Case for Health System Strengthening.Frontiers in surgery · 2021Article
- The CURE Protocol: evaluation and external validation of a new public health strategy for treating paediatric hydrocephalus in low-resource settings.BMJ global health · 2020Article
- A Systematic Review of Neurosurgical Care in Low-Income Countries.World neurosurgery: X · 2020Review
- Factors affecting ventriculoperitoneal shunt survival in adult patients.Surgical neurology international · 2015Article
- Hydrocephalus in children less than 1 year of age in northern Mozambique.Surgical neurology international · 2014Article
- Analysis of factors affecting ventriculoperitoneal shunt survival in pediatric patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Article
- Hydrocephalus associated with neural tube defects: characteristics, management, and outcome in sub-Saharan Africa.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSurgery for children in developing nations is challenging. Endoscopic third ventriculostomy (ETV) is an important surgical treatment for childhood hydrocephalus and has been performed in developing nations, but with lower success rates than in developed nations. It is not known if the lower success rate is due to inherent differences in prognostic factors.
methodsWe analyzed a large cohort of children (≤20 years old) treated with ETV in developed nations (618 patients from Canada, Israel, United Kingdom) and developing nations of sub-Saharan Africa (979 patients treated in Uganda). Risk-adjusted survival analysis was performed.
resultsThe risk of an intra-operative ETV failure (an aborted procedure) was significantly higher in Uganda regardless of risk adjustment (hazard ratio (HR), 95% confidence interval (CI), 11.00 (6.01 to 19.84) P<0.001). After adjustment for patient prognostic factors and technical variation in the procedure (the use of choroid plexus cauterization), there was no difference in the risk of failure for completed ETVs (HR, 95% CI, 1.04 (0.83 to 1.29), P=0.74).
conclusionsThree factors account for all significant differences in ETV failure between Uganda and developed nations: patient prognostic factors, technical variation in the procedure, and intra-operatively aborted cases. Once adjusted for these, the response to completed ETVs of children in Uganda is no different than that of children in developed nations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.