Evidence map›Paper›PMID 20552053›Full record

ArticleFrontiers in aging neuroscience2009

Susceptibility to Calcium Dysregulation during Brain Aging.

Ashok Kumar, Karthik Bodhinathan, Thomas C Foster

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Downregulation of striatal CaNeurobiology of disease · 2023
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Mitochondrial CaCells · 2021
    Review
  18. Review
  19. Extracellular ZnBiological trace element research · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ashok KumarDepartment of Neuroscience, McKnight Brain Institute, University of Florida Gainesville, FL, USA.
Karthik Bodhinathan
Thomas C Foster
University of Florida · US

Funding

MECHANISMS FOR ALTERED SYNAPTIC FUNCTION DURING AGINGR01AG014979 · NIA · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI FOSTER, THOMAS C · 1998 to 2011
$2.5M
ESTROGEN AND COGNITION OVER THE LIFESPANR01MH059891 · NIMH · UNIVERSITY OF KENTUCKY · PI FOSTER, THOMAS C · 2000 to 2009
$2.2M
NIA NIH HHS R01 AG014979NIMH NIH HHS R01 MH059891
6 · The paper itself

Abstract

Calcium (Ca(2+)) is a highly versatile intracellular signaling molecule that is essential for regulating a variety of cellular and physiological processes ranging from fertilization to programmed cell death. Research has provided ample evidence that brain aging is associated with altered Ca(2+) homeostasis. Much of the work has focused on the hippocampus, a brain region critically involved in learning and memory, which is particularly susceptible to dysfunction during senescence. The current review takes a broader perspective, assessing age-related changes in Ca(2+) sources, Ca(2+) sequestration, and Ca(2+) binding proteins throughout the nervous system. The nature of altered Ca(2+) homeostasis is cell specific and may represent a deficit or a compensatory mechanism, producing complex patterns of impaired cellular function. Incorporating the knowledge of the complexity of age-related alterations in Ca(2+) homeostasis will positively shape the development of highly effective therapeutics to treat brain disorders.

Indexed as

agingbraincalcium homeostasiscognitive impairmentshippocampusintracellular calcium storesN-methyl-d-aspartate receptorvoltage-dependent calcium channels

Identifiers

PMID20552053
PMCPMC2874411
OpenAlexW2078684933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.