Evidence map›Paper›PMID 20552044›Full record

ArticleFrontiers in aging neuroscience2010

KIBRA: A New Gateway to Learning and Memory?

Armin Schneider, Matthew J Huentelman, Joachim Kremerskothen, Kerstin Duning, Robert Spoelgen, Karoly Nikolich

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Genes · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice.International journal of molecular sciences · 2021
    Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Distinctive phosphoinositide- and CaThe Journal of biological chemistry · 2018
    Article
  14. The role of KIBRA in reconstructive episodic memory.Molecular medicine (Cambridge, Mass.) · 2018
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Armin SchneiderSYGNIS Bioscience Heidelberg, Germany.
Matthew J Huentelman
Joachim Kremerskothen
Kerstin Duning
Robert Spoelgen
Karoly Nikolich

Funding

Genetic Variation in KIBRA and its role in Human Episodic MemoryR01NS059873 · NINDS · TRANSLATIONAL GENOMICS RESEARCH INST · PI HUENTELMAN, MATT · 2008 to 2011
$1.4M
NINDS NIH HHS R01 NS059873
6 · The paper itself

Abstract

The genetic locus encoding KIBRA, a member of the WWC family of proteins, has recently been shown to be associated with human memory performance through genome-wide single nucleotide polymorphism screening. Gene expression analysis and a variety of functional studies have further indicated that such a role is biologically plausible for KIBRA. Here, we review the existing literature, illustrate connections between the different lines of evidence, and derive models based on KIBRA's function(s) in the brain that can be further tested experimentally.

Indexed as

Alzheimer's diseasecognitioncognitive impairmentgenome-wide association study (GWAS)hippocampusmemoryPKCζ

Identifiers

PMID20552044
PMCPMC2874402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.