Evidence map›Paper›PMID 20552039›Full record

ArticleInmunologia (Barcelona, Spain : 1987)2007

Role of lymphotoxin and homeostatic chemokines in the development and function of local lymphoid tissues in the respiratory tract.

Javier Rangel-Moreno, Damian Carragher, Troy D Randall

Abstract read
In one paragraph

Article in Inmunologia (Barcelona, Spain : 1987), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Javier Rangel-MorenoTrudeau Institute, Saranac Lake, NY 12983 USA.
Damian Carragher
Troy D Randall

Funding

Unique Aspects of Respiratory ImmunityR01HL069409 · NHLBI · UNIVERSITY OF ROCHESTER · PI RANDALL, TROY D · 2001 to 2015
$5.3M
Generation of effective memory CD8 T cells to influenzaR01AI061511 · NIAID · UNIVERSITY OF ROCHESTER · PI RANDALL, TROY D · 2005 to 2009
$1.8M
Function of NALT in nasal immunization to heterotypic strains of influenzaR01AI072689 · NIAID · UNIVERSITY OF ROCHESTER · PI RANDALL, TROY D · 2007 to 2010
$1.5M
NHLBI NIH HHS R01 HL069409NIAID NIH HHS R01 AI061511NIAID NIH HHS R01 AI072689
6 · The paper itself

Abstract

Secondary lymphoid organs are strategically placed to recruit locally activated antigen presenting cells (APCs) as well as naïve, recirculating T and B cells. The structure of secondary lymphoid organs - separated B and T zones, populations of specialized stromal cells, high endothelial venules and lymphatic vessles - has also evolved to maximize encounters between APCs and lymphocytes and to facilitate the expansion and differentiation of antigen-stimulated T and B cells. Many of the general mechanisms that govern the development and organization of secondary lymphoid organs have been identified over the last decade. However, the specific cellular and molecular interactions involved in the development and organization of each secondary lymphoid organ are slightly different and probably reflect the cell types available at that time and location. Here we review the mechanisms involved in the development, organization and function of local lymphoid tissues in the respiratory tract, including Nasal Associated Lymphoid Tissue (NALT) and inducible Bronchus Associated Lymphoid Tissue (iBALT).

Identifiers

PMID20552039
PMCPMC2884405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.