ArticleJournal of wound care2010
Testing wound dressings using an in vitro wound model.
Article in Journal of wound care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 74 citations in OpenAlex.
- Efficacy and cost-effectiveness of octenidine wound gel in the treatment of chronic venous leg ulcers in comparison to modern wound dressings.International wound journal · 2016Trial
- Efficacy of a novel thermo-reversible wound gel against antibiotic tolerant biofilm.Frontiers in antibiotics · 2026Article
- A Three-Dimensional Model of Bacterial Biofilms and Its Use in Antimicrobial Susceptibility Testing.Microorganisms · 2024Article
- Quantitative Insights and Visualization of Antimicrobial Tolerance in Mixed-Species Biofilms.Biomedicines · 2023Article
- Anti-Biofilm Efficacy of Commonly Used Wound Care Products in In Vitro Settings.Antibiotics (Basel, Switzerland) · 2023Article
- Development ofMolecular pharmaceutics · 2023Article
- Polyhexanide-Releasing Membranes for Antimicrobial Wound Dressings: A Critical Review.Membranes · 2022Review
- 3D Biofilm Models Containing Multiple Species for Antimicrobial Testing of Wound Dressings.Microorganisms · 2022Article
- In Vitro Wound Dressing Stack Model as a First Step to Evaluate the Behavior of Dressing Materials in Wound Bed-An Assessment of Mass Transport Phenomena in Hydrogel Wound Dressings.Materials (Basel, Switzerland) · 2021Article
- Sheep as a Potential Model of Intradiscal Infection by the BacteriumVeterinary sciences · 2021Article
- The Ability of a Concentrated Surfactant Gel to Reduce an Aerobic, Anaerobic and Multispecies Bacterial Biofilm In Vitro.Advances in experimental medicine and biology · 2021Article
- A multimodel regime for evaluating effectiveness of antimicrobial wound care products in microbial biofilms.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2020Article
- A Comparison of the Effects of Topical Prolavacid Solution (a Polyhexamethylene Biguanide-Based Wound Cleanser) and Medihoney Ointment in a Rat Model of Cutaneous Wound.Advances in wound care · 2017Article
- Biofilms and delayed healing - an in vitro evaluation of silver- and iodine-containing dressings and their effect on bacterial and human cells.International wound journal · 2017Article
- Physicians' knowledge and attitudes in the management of wound infection.International wound journal · 2016Article
- Growth of MRSA and Pseudomonas aeruginosa in a fine-celled foam model containing sessile commensal skin bacteria.Biofouling · 2016Article
- Quantitative NMR metabolite profiling of methicillin-resistant and methicillin-susceptible Staphylococcus aureus discriminates between biofilm and planktonic phenotypes.Journal of proteome research · 2014Article
- Evaluation of various silver-containing dressing on infected excision wound healing study.Journal of materials science. Materials in medicine · 2014Article
- Article
- A Novel Qualitative and Quantitative Biofilm Assay Based on 3D Soft Tissue.International journal of biomaterials · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether or not there are any significant differences in the effects of wound dressings on bacterial bioburden.
methodA selection of non-occlusive, non-adhesive dressings was tested for their effect on bacterial bioburden. The dressings selected included two dressings with antimicrobial properties (one containing silver and one containing PHMB), a cotton-based dressing enclosed in a perforated sleeve of poly(ethylene terephthalate), a carboxymethyl cellulose-based dressing, a fibre-free alginate dressing, and a 12-ply 100% cotton gauze. Using the colony-drip flow reactor (DFR) model, a meticillin-resistant Staphylococcus aureus (MRSA) or Pseudomonas aeruginosa biofilm was grown underneath a dressing sample. Biofilm growth was examined via plate counts, fluorescent microscopy and scanning electron microscopy.
resultsThe dressings containing antimicrobial agents had the greatest effect on bacterial load. In the MRSA experiments, both antimicrobial dressings produced lower bacteria counts than the other dressings (p<0.001), while in the P. aeruginosa experiments, only the silver-containing sample had fewer bacteria (p<0.0001). However, neither antimicrobial dressing was able to completely eradicate the bacteria when testing with either microorganism.
conclusionThe results presented herein illustrate that bacteria can grow unchallenged within the dressing environment and that an antimicrobial dressing can limit this bacterial growth. DECLARATION OF INTEREST: None.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.