ArticleJournal of epidemiology2010
Risk factors for colon cancer in Northeastern Thailand: interaction of MTHFR codon 677 and 1298 genotypes with environmental factors.
Article in Journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 10 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 10 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer.BMC cancer · 2025Pooled it
- Unveiling the link: Evaluating MTHFR gene polymorphisms and colorectal cancer risk through meta-analysis.PloS one · 2025Pooled it
- Associations between the consumption of red meat and processed meat and the incidence of colorectal cancer in Asia: a meta-analysis.Frontiers in medicine · 2025Pooled it
- Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis.Bioscience reports · 2017Pooled it
- Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Pooled it
- The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and tumor risk: evidence from 134 case-control studies.Molecular biology reports · 2014Pooled it
- A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk.Molecular biology reports · 2013Pooled it
- Pooled it
- Quantitative assessment of the association between MTHFR C677T polymorphism and colorectal cancer risk in East Asians.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Pooled it
- MTHFR C677T polymorphism contributes to colorectal cancer susceptibility: evidence from 61 case-control studies.Molecular biology reports · 2012Pooled it
- An ensemble machine learning approach for predicting colorectal polyps using novel inflammatory markers.BMC gastroenterology · 2026Article
- Dietary folate education versus once-weekly iron folic acid supplementation for improving folate status in reproductive-aged women: a quasi-experimental study.BMC nutrition · 2026Article
- Colonic neoplasm detection in patients withBMJ open · 2025Article
- Microbiome and biofilm insights from normal vs tumor tissues in Thai colorectal cancer patients.NPJ precision oncology · 2025Article
- Article
- Influence ofOpen life sciences · 2023Article
- Diet, obesity and colorectal carcinoma risk: results from a national cancer registry-based middle-eastern study.BMC cancer · 2018Article
- A potential role of probiotics in colorectal cancer prevention: review of possible mechanisms of action.World journal of microbiology & biotechnology · 2014Review
- Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta-analysis.Biomedical reports · 2013Article
- Folate Intake, MTHFR Polymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis.Journal of cancer epidemiology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolymorphisms in methylenetetrahydrofolate reductase (MTHFR), such as MTHFR C677T and A1298C, are associated with several cancers. This study aimed to evaluate the effects of MTHFR polymorphisms on colon cancer risk and possible interactions with environmental factors in a population from northeastern Thailand.
methodsThis hospital-based case-control study was conducted during 2002-2006; 130 colon cancer cases and 130 age- and sex-matched controls were enrolled. Information was collected and blood samples were obtained for assay of MTHFR C677T and A1298C polymorphisms by polymerase chain reaction with restriction fragment length polymorphism techniques. Associations between variables of interest and colon cancer were assessed using conditional logistic regression.
resultsIncreased risk of colon cancer was associated with alcohol consumption and bowel habits. Alcohol drinkers who consumed < or = 0.50 or >0.50 units of alcohol per day had elevated risks (OR(adj) = 3.5; 95% CI: 1.19-10.25 and OR(adj) = 1.71; 95% CI: 0.74-3.96, respectively). The risk was also higher in subjects with frequent constipation (11.69; 2.18-62.79) and occasional constipation (3.43; 1.72-6.82). An interaction was observed between the MTHFR C677T polymorphism and freshwater fish consumption on colon cancer risk (P value for interaction = 0.031). Interactions were observed between the MTHFR A1298C polymorphism and bowel habits, family history of cancer, alcohol consumption, and beef consumption on colon cancer risk (P-value for interaction = 0.0005, 0.007, 0.067, 0.003, respectively).
conclusionsIn a Thai population, colon cancer risk was associated with alcohol and beef consumption, bowel habits, and family history of cancer. Interactions between MTHFR polymorphisms and environmental factors were also observed.
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