ArticleGenetics2010
Nested association mapping for identification of functional markers.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Beyond the genome: the role of functional markers in contemporary plant breeding.Frontiers in plant science · 2025Review
- Dissecting the Genetic Architecture of Carbon Partitioning in Sorghum Using Multiscale Phenotypes.Frontiers in plant science · 2022Article
- Genetic characterization of a Sorghum bicolor multiparent mapping population emphasizing carbon-partitioning dynamics.G3 (Bethesda, Md.) · 2021Article
- Strategies to Assure Optimal Trade-Offs Among Competing Objectives for the Genetic Improvement of Soybean.Frontiers in genetics · 2021Article
- Crossword: A data-driven simulation language for the design of genetic-mapping experiments and breeding strategies.Scientific reports · 2019Article
- Fine-mapping and validation of the genomic region underpinning pear red skin colour.Horticulture research · 2019Article
- Relevance of genetic relationship in GWAS and genomic prediction.Journal of applied genetics · 2018Article
- Quantitative trait loci from identification to exploitation for crop improvement.Plant cell reports · 2017Review
- Maximizing the potential of multi-parental crop populations.Applied & translational genomics · 2016Review
- Emerging Genomic Tools for Legume Breeding: Current Status and Future Prospects.Frontiers in plant science · 2016Review
- Nested Association Mapping of Stem Rust Resistance in Wheat Using Genotyping by Sequencing.PloS one · 2016Article
- Combined linkage and linkage disequilibrium QTL mapping in multiple families of maize (Zea mays L.) line crosses highlights complementarities between models based on parental haplotype and single locus polymorphism.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- Novel genomic approaches unravel genetic architecture of complex traits in apple.BMC genomics · 2013Article
- Family-based association mapping in crop species.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Review
- Joint QTL linkage mapping for multiple-cross mating design sharing one common parent.PloS one · 2011Article
- In silico genotyping of the maize nested association mapping population.Molecular breeding : new strategies in plant improvement · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identification of functional markers (FMs) provides information about the genetic architecture underlying complex traits. An approach that combines the strengths of linkage and association mapping, referred to as nested association mapping (NAM), has been proposed to identify FMs in many plant species. The ability to identify and resolve FMs for complex traits depends upon a number of factors including frequency of FM alleles, magnitudes of their genetic effects, disequilibrium among functional and nonfunctional markers, statistical analysis methods, and mating design. The statistical characteristics of power, accuracy, and precision to identify FMs with a NAM population were investigated using three simulation studies. The simulated data sets utilized publicly available genetic sequences and simulated FMs were identified using least-squares variable selection methods. Results indicate that FMs with simple additive genetic effects that contribute at least 5% to the phenotypic variability in at least five segregating families of a NAM population consisting of recombinant inbred progeny derived from 28 matings with a single reference inbred will have adequate power to accurately and precisely identify FMs. This resolution and power are possible even for genetic architectures consisting of disequilibrium among multiple functional and nonfunctional markers in the same genomic region, although the resolution of FMs will deteriorate rapidly if more than two FMs are tightly linked within the same amplicon. Finally, nested mating designs involving several reference parents will have a greater likelihood of resolving FMs than single reference designs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.