ArticleGenetics2010
Regulation of odor receptor genes in trichoid sensilla of the Drosophila antenna.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- The Ortholog Receptor Or67d in Drosophila Bipectinata is able to Detect Two Different Pheromones.Journal of chemical ecology · 2024Article
- Article
- Large-scale characterization of sex pheromone communication systems in Drosophila.Nature communications · 2021Article
- Olfactory Receptor Gene Regulation in Insects: Multiple Mechanisms for Singular Expression.Frontiers in neuroscience · 2021Review
- Review
- Linking neuronal lineage and wiring specificity.Neural development · 2018Review
- The Two Main Olfactory Receptor Families inFrontiers in cellular neuroscience · 2018Review
- An accelerated miRNA-based screen implicates Atf-3 in Drosophila odorant receptor expression.Scientific reports · 2016Article
- Cis-regulatory mechanisms for robust olfactory sensory neuron class-restricted odorant receptor gene expression in Drosophila.PLoS genetics · 2015Article
- The putative Na⁺/Cl⁻-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis.Scientific reports · 2015Article
- Epigenetic regulation of olfactory receptor gene expression by the Myb-MuvB/dREAM complex.Genes & development · 2012Article
- Article
- Antennal expression pattern of two olfactory receptors and an odorant binding protein implicated in host odor detection by the malaria vector Anopheles gambiae.International journal of biological sciences · 2010Article
- Mechanisms of olfactory receptor neuron specification in Drosophila.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This study concerns the problem of odor receptor gene choice in the fruit fly Drosophila melanogaster. From a family of 60 Odor receptor genes, only one or a small number are selected for expression by each olfactory receptor neuron. Little is known about how an olfactory receptor neuron selects a receptor, or how the nucleotide sequences flanking a receptor gene dictate its expression in a particular neuron. Previous investigation has primarily concerned the maxillary palp, the simpler of the fly's two olfactory organs. Here we focus on genes encoding four antennal receptors that respond to fly odors in an in vivo expression system. To investigate the logic of odor receptor expression, we carry out a genetic analysis of their upstream regulatory sequences. Deletion analysis reveals that relatively short regulatory regions are sufficient to confer expression in the appropriate neurons, with limited if any misexpression. We find evidence for both positive and negative regulation. Multiple repressive functions restrict expression to the antenna, to a region of the antenna, and to neurons. Through deletion and base substitution mutagenesis we identify GCAATTA elements and find evidence that they act in both positive and negative regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.