ArticleThe Journal of biological chemistry2010
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B (CideB).
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway.Molecular metabolism · 2024Article
- Hypomethylated leptin receptor reduces cerebral ischaemia-reperfusion injury by activating the JAK2/STAT3 signalling pathway.The Journal of international medical research · 2024Article
- Effects of paraprobiotics on bile acid metabolism and liver health in largemouth bass (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Cardio-Oncology: mechanisms of cardiovascular toxicity.F1000Research · 2018Review
- CIDE Family-Mediated Unique Lipid Droplet Morphology in White Adipose Tissue and Brown Adipose Tissue Determines the Adipocyte Energy Metabolism.Journal of atherosclerosis and thrombosis · 2017Review
- Roles of silent information regulator 1-serine/arginine-rich splicing factor 10-lipin 1 axis in the pathogenesis of alcohol fatty liver disease.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- CIDE gene expression in adipose tissue, liver, and skeletal muscle from obese and lean pigs.Journal of Zhejiang University. Science. B · 2017Article
- Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.Current molecular pharmacology · 2017Review
- Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A.Scientific reports · 2016Article
- Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice.Journal of lipid research · 2015Article
- Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100.Molecular biology of the cell · 2015Article
- Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice.Endocrinology · 2014Article
- Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice.The Journal of biological chemistry · 2014Article
- Endoplasmic reticulum stress links hepatitis C virus RNA replication to wild-type PGC-1α/liver-specific PGC-1α upregulation.Journal of virology · 2014Article
- Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.Hepatology (Baltimore, Md.) · 2013Article
- CideB protein is required for the biogenesis of very low density lipoprotein (VLDL) transport vesicle.The Journal of biological chemistry · 2013Article
- Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis.Cell metabolism · 2012Article
- Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation.Journal of lipid research · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Abnormalities in very low density lipoprotein (VLDL) assembly and secretion impact intrahepatic lipid homeostasis, plasma lipoprotein profile, and energy metabolism of distal peripheral tissues. We have evaluated the role of the transcriptional coactivator, the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), in VLDL assembly and secretion. PGC-1alpha overexpression in HepG2 cells led to diminished rates of triglyceride (TG) synthesis but strongly stimulated VLDL-TG secretion, markedly increasing the efficiency of secretion of newly synthesized TG. PGC-1alpha overexpression increased the rate of secretion of apoB100 and promoted secretion of larger, less dense VLDL particles. PGC-1alpha overexpression in intact mouse liver also stimulated rates of VLDL TG secretion and attenuated hepatic TG accumulation resulting from high fat diet feeding. To determine the molecular mechanisms mediating the effect of PGC-1alpha on VLDL assembly, we evaluated the expression of several candidate mediators known to be involved in VLDL assembly or hepatic lipid homeostasis. Cell death-inducing DFFA-like effector B (CideB) expression was greatly induced by PGC-1alpha, and siRNA against CideB reversed the effects of PGC-1alpha on the secretion of TG and VLDL-sized particles by HepG2 cells, indicating that CideB is a critical mediator of stimulatory effects of PGC-1alpha on VLDL secretion. Collectively, these data suggest that PGC-1alpha plays an important role in partitioning cytoplasmic TG toward the VLDL secretory compartments and promoting VLDL secretion via transcriptional induction of CideB.
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