ArticleMolecular biology and evolution2010
Large-scale analysis of orthologs and paralogs under covarion-like and constant-but-different models of amino acid evolution.
Article in Molecular biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- A Phylogenetic Rate Parameter Indicates Different Sequence Divergence Patterns in Orthologs and Paralogs.Journal of molecular evolution · 2020Article
- Further Simulations and Analyses Demonstrate Open Problems of Phylostratigraphy.Genome biology and evolution · 2017Article
- Tissue-Specificity of Gene Expression Diverges Slowly between Orthologs, and Rapidly between Paralogs.PLoS computational biology · 2016Article
- Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout.Molecular biology and evolution · 2016Article
- Understanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach.Open biology · 2014Article
- Interchanging functionality among homologous elongation factors using signatures of heterotachy.Journal of molecular evolution · 2013Article
- Complex patterns of divergence among green-sensitive (RH2a) African cichlid opsins revealed by Clade model analyses.BMC evolutionary biology · 2012Article
- The evolution of novelty in conserved gene families.International journal of evolutionary biology · 2012Article
- Multidimensional scaling reveals the main evolutionary pathways of class A G-protein-coupled receptors.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional divergence between homologous proteins is expected to affect amino acid sequences in two main ways, which can be considered as proxies of biochemical divergence: a "covarion-like" pattern of correlated changes in evolutionary rates, and switches in conserved residues ("conserved but different"). Although these patterns have been used in case studies, a large-scale analysis is needed to estimate their frequency and distribution. We use a phylogenomic framework of animal genes to answer three questions: 1) What is the prevalence of such patterns? 2) Can we link such patterns at the amino acid level with selection inferred at the codon level? 3) Are patterns different between paralogs and orthologs? We find that covarion-like patterns are more frequently detected than "constant but different," but that only the latter are correlated with signal for positive selection. Finally, there is no obvious difference in patterns between orthologs and paralogs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.