ArticleBiophysical journal2010
Heterogeneous diffusion of a membrane-bound pHLIP peptide.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Kinetics of peptide folding in lipid membranes.Biopolymers · 2015Review
- Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP.Archives of biochemistry and biophysics · 2015Article
- Targeting diseased tissues by pHLIP insertion at low cell surface pH.Frontiers in physiology · 2014Review
- pH-controlled delivery of luminescent europium coated nanoparticles into platelets.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Spectroscopic studies of protein folding: linear and nonlinear methods.Protein science : a publication of the Protein Society · 2012Review
- Photoinduced electron transfer and fluorophore motion as a probe of the conformational dynamics of membrane proteins: application to the influenza a M2 proton channel.Langmuir : the ACS journal of surfaces and colloids · 2011Article
- Diffusion as a probe of peptide-induced membrane domain formation.Biochemistry · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lateral diffusion of cell membrane constituents is a prerequisite for many biological functions. However, the diffusivity (or mobility) of a membrane-bound species can be influenced by many factors. To provide a better understanding of how the conformation and location of a membrane-bound biological molecule affect its mobility, herein we study the diffusion properties of a pH low insertion peptide (pHLIP) in model membranes using fluorescence correlation spectroscopy. It is found that when the pHLIP peptide is located on the membrane surface, its lateral diffusion is characterized by a distribution of diffusion times, the characteristic of which depends on the peptide/lipid ratio. Whereas, under conditions where pHLIP adopts a well-defined transmembrane alpha-helical conformation the peptide still exhibits heterogeneous diffusion, the distribution of diffusion times is found to be independent of the peptide/lipid ratio. Taken together, these results indicate that the mobility of a membrane-bound species is sensitive to its conformation and location and that diffusion measurement could provide useful information regarding the conformational distribution of membrane-bound peptides. Furthermore, the observation that the mobility of a membrane-bound species depends on its concentration may have important implications for diffusion-controlled reactions taking place in membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.