ArticleBiophysical journal2010
A model of fibroblast motility on substrates with different rigidities.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- A Model for the Diversity Explosion Fundamental to Metastasis.bioRxiv : the preprint server for biology · 2025Article
- In silico analysis shows that dynamic changes in curvature guide cell migration over long distances.Biomechanics and modeling in mechanobiology · 2024Article
- A multiscale theory for spreading and migration of adhesion-reinforced mesenchymal cells.Journal of the Royal Society, Interface · 2023Article
- Environmental stiffness restores mechanical homeostasis in vimentin-depleted cells.Scientific reports · 2023Article
- A multiscale whole-cell theory for mechanosensitive migration on viscoelastic substrates.Biophysical journal · 2023Article
- Article
- Durotaxis: the mechanical control of directed cell migration.The FEBS journal · 2022Review
- Cellular mechanics of wound formation in single cell layer under cyclic stretching.Biophysical journal · 2022Article
- The interplay between physical cues and mechanosensitive ion channels in cancer metastasis.Frontiers in cell and developmental biology · 2022Review
- Interplay among cell migration, shaping, and traction force on a matrix with cell-scale stiffness heterogeneity.Biophysics and physicobiology · 2022Article
- Rheological Properties of Coordinated Physical Gelation and Chemical Crosslinking in Gelatin Methacryloyl (GelMA) Hydrogels.Macromolecular bioscience · 2020Article
- Two-Photon Polymerized Poly(2-Ethyl-2-Oxazoline) Hydrogel 3D Microstructures with Tunable Mechanical Properties for Tissue Engineering.Molecules (Basel, Switzerland) · 2020Article
- Cell-substrate mechanics guide collective cell migration through intercellular adhesion: a dynamic finite element cellular model.Biomechanics and modeling in mechanobiology · 2020Article
- Cell Shape and Durotaxis Explained from Cell-Extracellular Matrix Forces and Focal Adhesion Dynamics.iScience · 2020Article
- A mechanical toy model linking cell-substrate adhesion to multiple cellular migratory responses.Journal of biological physics · 2019Article
- Mechanical Model for Durotactic Cell Migration.ACS biomaterials science & engineering · 2019Article
- Mechanochemical Coupling and Junctional Forces during Collective Cell Migration.Biophysical journal · 2019Article
- Emerging roles for LPP in metastatic cancer progression.Journal of cell communication and signaling · 2018Review
- Computational modeling of single-cell mechanics and cytoskeletal mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- Stiffness-dependent motility and proliferation uncoupled by deletion of CD44.Scientific reports · 2017Article
Corrections and comments
- Erratum issuedCorrection.2011
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To function efficiently in the body, the biological cells must have the ability to sense the external environment. Mechanosensitivity toward the extracellular matrix was identified as one of the sensing mechanisms affecting cell behavior. It was shown experimentally that a fibroblast cell prefers locomoting over the stiffer substrate when given a choice between a softer and a stiffer substrate. In this article, we develop a discrete model of fibroblast motility with substrate-rigidity sensing. Our model allows us to understand the interplay between the cell-substrate sensing and the cell biomechanics. The model cell exhibits experimentally observed substrate rigidity sensing, which allows us to gain additional insights into the cell mechanosensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.