ArticleRespiratory research2010
Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE study.
Article in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03924843 (Responsivity and Reproducibility of Messenger and Micro RNA Airway Inflammatory Markers - a Pilot Study), which is not on this map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Responsivity and Reproducibility of Messenger and Micro RNA Airway Inflammatory Markers - a Pilot Study
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 168 citations in OpenAlex.
- p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics.Cell communication and signaling : CCS · 2023Pooled it
- The YKL-40 protein is a potential biomarker for COPD: a meta-analysis and systematic review.International journal of chronic obstructive pulmonary disease · 2018Pooled it
- Neutrophil elastase as a biomarker for bacterial infection in COPD.Respiratory research · 2019Trial
- Acceptability of sputum specimens for diagnosing pulmonary tuberculosis.Journal of Korean medical science · 2015Trial
- Anti-inflammatory effects of salmeterol/fluticasone propionate 50/250 mcg combination therapy in Japanese patients with chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2015Trial
- Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.American journal of respiratory and critical care medicine · 2012Trial
- Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026Review
- Radiomic analysis of computed tomography scans in COPD patients relates to different clinical and biological features, and identifies different lung function trajectories during follow-up.ERJ open research · 2026Article
- The Evolving Landscape of COPD Typization.Medicina (Kaunas, Lithuania) · 2026Review
- Neutrophil heterogeneity and plasticity: unveiling the multifaceted roles in health and disease.MedComm · 2025Review
- Blocking IL-23 Signaling Mitigates Cigarette Smoke-Induced Murine Emphysema.Environmental toxicology · 2024Article
- Self-report underestimates the frequency of the acute respiratory exacerbations of COPD but is associated with BAL neutrophilia and lymphocytosis: an observational study.BMC pulmonary medicine · 2024Observational
- What every clinician should know about inflammation in COPD.ERJ open research · 2024Review
- The cGAS-STING pathway in COPD: targeting its role and therapeutic potential.Respiratory research · 2024Review
- Phenotype to Treatable Traits-Based Management in Chronic Obstructive Pulmonary Disease.Cureus · 2024Review
- Inflammation as the nexus: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease.Frontiers in cardiovascular medicine · 2024Review
- Bronchoalveolar Lavage Fluid from Chronic Obstructive Pulmonary Disease Patients Increases Neutrophil Chemotaxis Measured by a Microfluidic Platform.Micromachines · 2023Article
- Exacerbations of COPD.Respiratory care · 2023Article
- Inter-relationships among neutrophilic inflammation, air trapping and future exacerbation in COPD: an analysis of ECOPD study.BMJ open respiratory research · 2023Article
- Sputum neutrophil counts in healthy subjects: relationship with age.ERJ open research · 2022Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe percentage of neutrophils in sputum are increased in COPD patients, and may therefore be a biomarker of airway inflammation. We studied the relationships between sputum neutrophils and FEV1, health status, exacerbation rates, systemic inflammation and emphysema, and long term variability at 1 year.
methodsSputum samples were obtained from 488 COPD patients within the ECLIPSE cohort. 359 samples were obtained at baseline, and 297 after 1 year. 168 subjects provided samples at both visits. Serum interleukin-6 (IL-6), IL-8, surfactant protein D and C-reactive protein levels were measured by immunoassays. Low-dose CT scans evaluated emphysema.
resultsSputum neutrophil % increased with GOLD stage. There was a weak association between % sputum neutrophils and FEV1 % predicted (univariate r2 = 0.025 and 0.094 at baseline and year 1 respectively, p < 0.05 after multivariate regression). Similar weak but significant associations were observed between neutrophil % and health status measured using the St Georges Respiratory Questionairre. There were no associations between neutrophils and exacerbation rates or emphysema. Associations between sputum neutrophils and systemic biomarkers were non-significant or similarly weak. The mean change over 1 year in neutrophil % was an increase of 3.5%.
conclusionsSputum neutrophil measurements in COPD are associated weakly with FEV1 % predicted and health status. Sputum neutrophil measurements were dissociated from exacerbation rates, emphysema and systemic inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.