ArticleBMC evolutionary biology2010
Evolution of the CD163 family and its relationship to the bovine gamma delta T cell co-receptor WC1.
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 70 citations in OpenAlex.
- Biomarkers can predict potential clinical responders to DIMS0150 a toll-like receptor 9 agonist in ulcerative colitis patients.BMC gastroenterology · 2014Trial
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- Providing Standardized Gene Nomenclature for Domestic Ungulate Scavenger Receptor Genes.microPublication biology · 2025Article
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- Preferential differential gene expression within the WC1.1Frontiers in immunology · 2023Article
- Lymphocyte subsets in Atlantic cod (Gadus morhua) interrogated by single-cell sequencing.Communications biology · 2022Article
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- Defining the caprine γδ T cell WC1 multigenic array and evaluation of its expressed sequences and gene structure conservation among goat breeds and relative to cattle.Immunogenetics · 2022Article
- The WC1 γδ T cell pathogen receptor of ruminants is preserved in the genome of ancient extinct auroch.Immunogenetics · 2021Article
- Generation and first characterization of TRDC-knockout pigs lacking γδ T cells.Scientific reports · 2021Article
- Gamma Delta TCR and the WC1 Co-Receptor Interactions in Response toFrontiers in immunology · 2021Article
- Whole-Blood Transcriptome Analysis of Feedlot Cattle With and Without Bovine Respiratory Disease.Frontiers in genetics · 2021Article
- High expression of WTAP leads to poor prognosis of gastric cancer by influencing tumour-associated T lymphocyte infiltration.Journal of cellular and molecular medicine · 2020Article
- Distinct Features of Canine Non-conventional CD4Frontiers in immunology · 2019Article
- Haptoglobin Is a Divergent MASP Family Member That Neofunctionalized To Recycle Hemoglobin via CD163 in Mammals.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Variegated Transcription of the WC1 Hybrid PRR/Co-Receptor Genes by Individual γδ T Cells and Correlation With Pathogen Responsiveness.Frontiers in immunology · 2018Article
- Recent expansion and adaptive evolution of the carcinoembryonic antigen family in bats of the Yangochiroptera subgroup.BMC genomics · 2017Article
- A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Brief review of the chicken Major Histocompatibility Complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance.Poultry science · 2016Review
- Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction.Structure (London, England : 1993) · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe scavenger receptor cysteine rich (SRCR) domain is an ancient and conserved protein domain. CD163 and WC1 molecules are classed together as group B SRCR superfamily members, along with Spalpha, CD5 and CD6, all of which are expressed by immune system cells. There are three known types of CD163 molecules in mammals, CD163A (M130, coded for by CD163), CD163b (M160, coded for by CD163L1) and CD163c-alpha (CD163L1 or SCART), while their nearest relative, WC1, is encoded by a multigene family so far identified in the artiodactyl species of cattle, sheep, and pigs.
resultsWe annotated the bovine genome and identified genes coding for bovine CD163A and CD163c-alpha but found no evidence for CD163b. Bovine CD163A is widely expressed in immune cells, whereas CD163c-alpha transcripts are enriched in the WC1+ gammadelta T cell population. Phylogenetic analyses of the CD163 family genes and WC1 showed that CD163c-alpha is most closely related to WC1 and that chicken and platypus have WC1 orthologous genes, previously classified as among their CD163 genes.
conclusionSince it has been shown that WC1 plays an important role in the regulation of gammadelta T cell responses in cattle, which, like chickens, have a high percentage of gammadelta T cells in their peripheral blood, CD163c-alpha may play a similar role, especially in species lacking WC1 genes. Our results suggest that gene duplications resulted in the expansion of CD163c-alpha-like and WC1-like molecules. This expanded repertoire was retained by species known as "gammadelta T cell high", but homologous SRCR molecules were maintained by all mammals.
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