ArticleEpilepsia2010
Autoantibodies to glutamic acid decarboxylase in patients with epilepsy are associated with low cortical GABA levels.
Article in Epilepsia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 54 citations in OpenAlex.
- Recurrent Autoimmune Encephalitis in a Patient With Autoimmune Polyendocrine Syndrome Type 1.Case reports in critical care · 2026Article
- Excitatory-inhibitory imbalance in temporal lobe epilepsy: a 5T multimodal MRI biomarker for focus localization and drug resistance stratification.Frontiers in aging neuroscience · 2025Article
- N-methyl-D-aspartate receptor autoantibody levels in children with intractable and non-intractable epilepsy.Heliyon · 2024Article
- Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Immune Mechanisms in Epileptogenesis: Update on Diagnosis and Treatment of Autoimmune Epilepsy Syndromes.Drugs · 2023Review
- Musicogenic seizures in temporal lobe epilepsy: Case reports based on ictal source localization analysis.Frontiers in neurology · 2023Article
- The clinical relevance of anti-glutamic acid decarboxylase antibodies in children with encephalitis/encephalopathy.Frontiers in neuroscience · 2022Article
- Comparison of methods for spectral alignment and signal modelling of GABA-edited MR spectroscopy data.NeuroImage · 2021Article
- Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy.Scientific reports · 2021Article
- Cerebrospinal Fluid Findings of 36 Adult Patients with Autism Spectrum Disorder.Brain sciences · 2020Article
- HDAC4 gene silencing alleviates epilepsy by inhibition of GABA in a rat model.Neuropsychiatric disease and treatment · 2019Article
- Spatial variability and reproducibility of GABA-edited MEGA-LASER 3D-MRSI in the brain at 3 T.NMR in biomedicine · 2016Article
- Immunity and Inflammation in Epilepsy.Cold Spring Harbor perspectives in medicine · 2015Review
- Diabetes and epilepsy in children and adolescents.Current diabetes reports · 2015Review
- GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies.Pharmacology & therapeutics · 2014Review
- GABA-based evaluation of neurologic conditions: MR spectroscopy.AJNR. American journal of neuroradiology · 2013Review
- Proton MR spectroscopy-detectable major neurotransmitters of the brain: biology and possible clinical applications.AJNR. American journal of neuroradiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Antibodies to glutamic acid decarboxylase (GAD), the major pathway for the synthesis of c-aminobutyric acid(GABA) in humans, are found at elevated levels in a subgroup of patients with chronic epilepsy. To test whether the antibodies were associated with changes in cortical GABA levels we used magnetic resonance spectroscopy. Four patients with epilepsy and high serum GAD antibody levels (107-6,200 units/ml) and 10 healthy controls were recruited. A 3T GABA-optimized spectrum was obtained from a reproducible voxel in the cortex. Compared to the control group, the patient group had significantly lower GABA concentrations within the cortex. Demonstration of an association between high serum GAD antibodies and low cortical GABA levels in patients with epilepsy suggests that GAD antibodies are, at least, a marker of a specific disease process and support a role for immune-mediated GABAergic dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.