ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Specific isoforms of drosophila shroom define spatial requirements for the induction of apical constriction.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Decoding the Evolution and Co-Phospho-Regulatory Networks of SHROOM Proteins.Journal of molecular evolution · 2026Article
- A modifier screen identifies regulators of cytoskeletal architecture as mediators of Shroom-dependent changes in tissue morphology.Biology open · 2021Article
- Folic acid modifies the shape of epithelial cells during morphogenesis via a Folr1 and MLCK dependent mechanism.Biology open · 2019Article
- Review
- The force-sensitive protein Ajuba regulates cell adhesion during epithelial morphogenesis.The Journal of cell biology · 2018Article
- Characterization of Coding/Noncoding Variants forJournal of the American Society of Nephrology : JASN · 2018Article
- The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis.The Journal of cell biology · 2018Article
- Models of convergent extension during morphogenesis.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins.Journal of visualized experiments : JoVE · 2017Article
- Structure of the Shroom-Rho Kinase Complex Reveals a Binding Interface with Monomeric Shroom That Regulates Cell Morphology and Stimulates Kinase Activity.The Journal of biological chemistry · 2016Article
- E-cadherin junctions as active mechanical integrators in tissue dynamics.Nature cell biology · 2015Review
- The interaction between Shroom3 and Rho-kinase is required for neural tube morphogenesis in mice.Biology open · 2014Article
- A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation.Developmental cell · 2014Article
- Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling.Nature reviews. Molecular cell biology · 2014Review
- Apical constriction: themes and variations on a cellular mechanism driving morphogenesis.Development (Cambridge, England) · 2014Review
- Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition.Development (Cambridge, England) · 2014Article
- Rho GTPase and Shroom direct planar polarized actomyosin contractility during convergent extension.The Journal of cell biology · 2014Article
- Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology.PloS one · 2013Article
- Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.Molecular biology of the cell · 2012Article
- A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.Development (Cambridge, England) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vertebrate Shroom proteins define cytoskeletal organization and cellular architecture by binding directly to F-actin and Rho-kinase and spatially regulating the activity of nonmuscle myosin II (myosin II). Here, we report characterization and gain-of-function analysis of Drosophila Shroom. The dShrm locus expresses at least two protein isoforms, dShrmA and dShrmB, which localize to adherens junctions and the apical membrane, respectively. dShrmA and dShrmB exhibit differing abilities to induce apical constriction that are based on their subcellular distribution and the subsequent assembly of spatially and organizationally distinct actomyosin networks that are dependent on the ability to engage Rho-kinase and the activity of myosin II. These data show that the differential subcellular distribution of naturally occurring isoforms of Shroom proteins can define both the position and organization of actomyosin networks in vivo. We further hypothesize that differentially positioned contractile arrays have distinct effects on cellular morphologies and behaviors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.