Evidence map›Paper›PMID 20549560›Full record

ArticleMycopathologia2010

Building-associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment.

Enusha Karunasena, Michael D Larrañaga, Jan S Simoni, David R Douglas, David C Straus

Abstract read
PubMed Publisher
In one paragraph

Article in Mycopathologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Evolution of the Satratoxin and Atranone Gene Clusters ofJournal of fungi (Basel, Switzerland) · 2022
    Article
  6. Article
  7. Mast Cells, Stress, Fear and Autism Spectrum Disorder.International journal of molecular sciences · 2019
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Fungal pollution of indoor environments and its management.Saudi journal of biological sciences · 2012
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Enusha KarunasenaDepartment of Animal & Food Sciences, Texas Tech University, Lubbock, TX 79409, USA. enusha.karunasena@ttuhsc.edu
Michael D Larrañaga
Jan S Simoni
David R Douglas
David C Straus
Texas Tech University · USTexas Tech University Health Sciences Center · USOklahoma State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Damage to human neurological system cells resulting from exposure to mycotoxins confirms a previously controversial public health threat for occupants of water-damaged buildings. Leading scientific organizations disagree about the ability of inhaled mycotoxins in the indoor environment to cause adverse human health effects. Damage to the neurological system can result from exposure to trichothecene mycotoxins in the indoor environment. This study demonstrates that neurological system cell damage can occur from satratoxin H exposure to neurological cells at exposure levels that can be found in water-damaged buildings contaminated with fungal growth. The constant activation of inflammatory and apoptotic pathways at low levels of exposure in human brain capillary endothelial cells, astrocytes, and neural progenitor cells may amplify devastation to neurological tissues and lead to neurological system cell damage from indirect events triggered by the presence of trichothecenes.

Indexed as

ApoptosisStress, PhysiologicalAstrocytesCells, CulturedEndothelial CellsHumansNeural Stem CellsTrichothecenessatratoxin HTrichothecenes

Identifiers

PMID20549560
OpenAlexW2047017881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.