ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2010
Clinical and laboratory features of invasive community-onset methicillin-resistant Staphylococcus aureus infection: a prospective case-control study.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The antibacterial effectiveness of lavender essential oil against methicillin-resistantFrontiers in pharmacology · 2023Pooled it
- Reevaluation of the impact of methicillin-resistance on outcomes in patients with Staphylococcus aureus bacteremia and endocarditis.The Korean journal of internal medicine · 2019Pooled it
- The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2013Pooled it
- Socioeconomic status and the risk for colonisation or infection with priority bacterial pathogens: a global evidence map.The Lancet. Microbe · 2025Review
- Epidemiology and clinical features of Skin and Soft Tissue Infections Caused by PVL-Positive and PVL-Negative Methicillin-ResistantEmerging microbes & infections · 2024Article
- Socioeconomic status and the risk for colonization or infection with priority bacterial pathogens: a global evidence map.medRxiv : the preprint server for health sciences · 2024Article
- Prevalence ofMicroorganisms · 2023Article
- Multi-site infection by methicillin-resistant Staphylococcus aureus in a six-year old girl: a case report.BMC infectious diseases · 2022Article
- Epidemiological and clinical features of Panton-Valentine Leukocidin positive Staphylococcus aureus bacteremia: A case-control study.PloS one · 2022Article
- C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study.BMC infectious diseases · 2021Article
- Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms.FEMS microbiology reviews · 2020Review
- Incidence of community onset MRSA in Australia: least reported where it is Most prevalent.Antimicrobial resistance and infection control · 2019Article
- Increased Age-Dependent Risk of Death Associated WithOpen forum infectious diseases · 2016Article
- Epidemiological, clinical, outcome and antibiotic susceptibility differences between PVL positive and PVL negative Staphylococcus aureus infections in Western Australia: a case control study.BMC infectious diseases · 2015Article
- Clinical and molecular characteristics of invasive community-acquired Staphylococcus aureus infections in Chinese children.BMC infectious diseases · 2014Article
- Clinical and molecular epidemiology of community-onset invasive Staphylococcus aureus infection in New Zealand children.Epidemiology and infection · 2014Article
- Impact of ethnicity and socio-economic status on Staphylococcus aureus bacteremia incidence and mortality: a heavy burden in Indigenous Australians.BMC infectious diseases · 2012Article
- Draft genome sequences of Staphylococcus aureus sequence type 34 (ST34) and ST42 hybrids.Journal of bacteriology · 2012Article
- Predictors of mortality in Staphylococcus aureus Bacteremia.Clinical microbiology reviews · 2012Review
- Colonization, pathogenicity, host susceptibility, and therapeutics for Staphylococcus aureus: what is the clinical relevance?Seminars in immunopathology · 2012Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differences between the features of invasive community-onset methicillin-resistant Staphylococcus aureus (cMRSA) and methicillin-susceptible S. aureus (cMSSA) infections are incompletely understood. Fifty-seven patients with invasive cMRSA infection were prospectively identified at two teaching hospitals; for each cMRSA case, two cases of invasive cMSSA infection acted as controls. The primary outcome was 30-day all-cause mortality. Patients with invasive cMRSA infection were more likely to be Aboriginal (25% vs. 14%, age-adjusted odds ratio [OR] 2.5, p = 0.037), reside in a long-term care facility and/or have been hospitalised in the previous year (51% vs. 34%, p = 0.04) and less likely to have endocarditis (2% vs. 12%, p = 0.02) or require admission to an intensive care unit or high-dependency area (7% vs. 21%, p = 0.02). All-cause mortality at 30 days was similar in the cMRSA and cMSSA groups (9% vs. 7%, p = 0.68). Panton-Valentine leukocidin (PVL) genes were detected in a similar proportion of cMRSA and cMSSA isolates (32% vs. 27%, p = 0.49) and the presence of PVL genes was associated with younger age (35 years vs. 55 years, p < 0.001), Aboriginal ethnicity (38% vs. 10%, p < 0.001), skin and soft-tissue infection (54% vs. 19%, p < 0.001), lower illness severity at presentation (SAPS II score 9 vs. 21, p = 0.001) and shorter hospitalisation (9 days vs. 24 days, p < 0.001). Patients with "PVL-positive" and "PVL-negative" S. aureus infection had similar 30-day all-cause mortality (4% vs. 9%, p = 0.28). Few clinical features differentiated patients with invasive cMRSA infection from those with infection caused by cMSSA. Invasive "PVL-positive" S. aureus infection was associated with less morbidity but similar mortality to "PVL-negative" infection.
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