ReviewStem cell reviews and reports2010
Viable fertile mice generated from fully pluripotent iPS cells derived from adult somatic cells.
Review in Stem cell reviews and reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Making a good egg: human oocyte health, aging, and in vitro development.Physiological reviews · 2023Review
- Transcriptomic reprogramming for neuronal age reversal.Human genetics · 2023Article
- Lab partners: oocytes, embryos and company. A personal view on aspects of oocyte maturation and the development of monozygotic twins.Animal reproduction · 2023Article
- Urine-Derived Induced Pluripotent Stem Cells in Cardiovascular Disease.Cardiology research and practice · 2020Review
- Genome-wide gene expression analyses reveal unique cellular characteristics related to the amenability of HPC/HSCs into high-quality induced pluripotent stem cells.Stem cell research & therapy · 2016Article
- Topical Atropine in the Control of Myopia.Medical hypothesis, discovery & innovation ophthalmology journal · 2016Review
- Tetraploid complementation proves pluripotency of induced pluripotent stem cells derived from adipose tissue.Cell proliferation · 2015Article
- Gamete derivation from embryonic stem cells, induced pluripotent stem cells or somatic cell nuclear transfer-derived embryonic stem cells: state of the art.Reproduction, fertility, and development · 2014Review
- Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia.Haematologica · 2014Article
- Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery.Expert review of molecular diagnostics · 2014Review
- Stem cells as new agents for the treatment of infertility: current and future perspectives and challenges.BioMed research international · 2014Review
- Adult somatic cells to the rescue: nuclear reprogramming and the dispensability of gonadal germ cells.Fertility and sterility · 2014Review
- In vivo reprogramming in inflammatory bowel disease.Gene therapy · 2013Review
- Pluripotency of induced pluripotent stem cells.Genomics, proteomics & bioinformatics · 2013Review
- Stem cell therapeutic possibilities: future therapeutic options for male-factor and female-factor infertility?Reproductive biomedicine online · 2013Review
- Recent advances in the development of new transgenic animal technology.Cellular and molecular life sciences : CMLS · 2013Review
- Generation of mice derived from induced pluripotent stem cells.Journal of visualized experiments : JoVE · 2012Article
- Article
- New approaches in the differentiation of human embryonic stem cells and induced pluripotent stem cells toward hepatocytes.Stem cell reviews and reports · 2011Review
- Genomic instability in induced stem cells.Cell death and differentiation · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies demonstrated that induced pluripotent stem (iPS) cells could produce viable mice through tetraploid complementation, which was thought to be the most stringent test for pluripotency. However, these highly pluripotent iPS cells were previously reported to be generated from fibroblasts of embryonic origin. Achieving fully pluripotent iPS cells from multiple cell types, especially easily accessible adult tissues, will lead to a much greater clinical impact. We successfully generated high-pluripotency iPS cells from adult tail tip fibroblasts (TTF) that resulted in viable, full-term, fertile TTF-iPS animals with no obvious teratoma formation or other developmental abnormalities. Comparison of iPS cells from embryonic origin (MEF), progenitor cells (neural stem cells) or differentiated somatic cells (TTF) reveals that fully pluripotent developmental potential can be reached by each cell type, although with different induction efficiencies. This work provides the means for studying the mechanisms and regulation of direct reprogramming, and has encouraging implications for future clinical applications and therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.