ArticleParasitology research2010
Association between Toll-like receptor 2 (TLR2) polymorphisms and asymptomatic bancroftian filariasis.
Article in Parasitology research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The role of TLR2, TLR4 and CD14 genetic polymorphisms in gastric carcinogenesis: a case-control study and meta-analysis.PloS one · 2013Pooled it
- Association between TLR2 polymorphisms (- 196-174 Ins/Del, R677W, R753Q, and P631H) and schizophrenia in a Tunisian population.Immunologic research · 2021Trial
- Association between polymorphisms of TLR2-1-6 and bipolar disorder in a tunisian population.Molecular biology reports · 2023Article
- Augmented Innate and Adaptive Immune Responses Under Conditions of Diabetes-Filariasis Comorbidity.Frontiers in immunology · 2021Article
- Duplication mutation in CHIT1 gene is associated with poor response to medical therapy in patients affected with filarial chyluria.Bioinformation · 2020Article
- Evolutionary History of the Toll-Like Receptor Gene Family across Vertebrates.Genome biology and evolution · 2020Article
- The Genetic Polymorphisms of 24 Base Pair Duplication and Point G102S of Human Chitotriosidase to Bancroftian Filariasis at the Thai⁻Myanmar Border.Pathogens (Basel, Switzerland) · 2019Article
- The Prevalence of Lymphatic Filariasis in Elementary School Children Living in Endemic Areas: A Baseline Survey Prior to Mass Drug Administration in Pekalongan District-Indonesia.Iranian journal of public health · 2018Article
- Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa.Frontiers in genetics · 2018Review
- Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti.Human genomics · 2017Article
- Toll-Like Receptor-Mediated Free Radical Generation inThe Korean journal of parasitology · 2016Article
- Genetic predisposition of variants in TLR2 and its co-receptors to severe malaria in Odisha, India.Immunologic research · 2016Article
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
- Article
- Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseases.Clinical and experimental immunology · 2015Review
- Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders.PloS one · 2015Article
- Pattern-recognition receptors and gastric cancer.Frontiers in immunology · 2014Review
- Genome-wide screening identifies Plasmodium chabaudi-induced modifications of DNA methylation status of Tlr1 and Tlr6 gene promoters in liver, but not spleen, of female C57BL/6 mice.Parasitology research · 2013Article
- Article
- Immunopathogenesis of lymphatic filarial disease.Seminars in immunopathology · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphatic filariasis is mainly caused by the filarial nematodes Wuchereria bancrofti and Brugia malayi. Wolbachia, intracellular symbiotic bacteria in filarial parasite, is known to induce immune response predominantly through Toll-like receptor 2 (TLR2). This study was performed to investigate the association between polymorphisms of the TLR2 gene and susceptibility to asymptomatic bancroftian filariasis. A total of 142 unrelated asymptomatic bancroftian filariasis patients and 151 endemic normal controls in Tak province, Thailand were recruited into this study. The -196 to -173 deletion (del) polymorphism in the 5' untranslated region was investigated by allele-specific polymerase chain reaction. Two single nucleotide polymorphisms, +597 T>C and +1350 T>C, in exon 3 were identified by polymerase chain reaction-restriction fragment length polymorphism analysis. Furthermore, we analyzed the functional difference between the TLR2 -196 to -173 del and wild-type (wt) alleles using the luciferase reporter assay. All three polymorphisms were associated with a higher risk of asymptomatic bancroftian filariasis and were in strong linkage disequilibrium with each other. The TLR2 haplotype -196 to -173del/+597C/+1350C was strongly associated with an increased risk of asymptomatic bancroftian filariasis. The TLR2 -196 to -173 del allele had a significantly lower transcriptional activity than wt allele. The results of our study indicate that TLR2 -196 to -173 del, +597 T>C and +1350 T>C polymorphisms are associated with asymptomatic bancroftian filariasis in Thailand. Our functional study also supports this finding with respect to differential TLR2 gene expression by -196 to -173 del polymorphism.
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