ArticleThe Canadian journal of cardiology
Dose-response relationship between physical activity and dyslipidemia in youth.
Article in The Canadian journal of cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Non-linear effect of physical activity intervention on blood pressure in children and adolescents: a systematic review and dose-response meta-analysis.BMC public health · 2025Pooled it
- Effects of recreational football on body composition, cardiometabolic health, and functional performance in children and adolescents: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Dose-dependent effects of lifestyle interventions on blood lipid levels: Results from the PREMIER trial.Patient education and counseling · 2019Trial
- Ambivalence is associated with decreased physical activity and cardiorespiratory fitness among adolescents with critical congenital heart disease.Heart & lung : the journal of critical careTrial
- A cross-sectional study of 2Sports medicine and health science · 2026Article
- No or low self-reported moderate to vigorous physical activity among Chinese children and adolescents: a large-scale cross-sectional study.BMC public health · 2025Article
- Article
- Global prevalence and gender inequalities in at least 60 min of self-reported moderate-to-vigorous physical activity 1 or more days per week: An analysis with 707,616 adolescents.Journal of sport and health science · 2024Article
- Article
- Predicting dyslipidemia incidence: unleashing machine learning algorithms on Lifestyle Promotion Project data.BMC public health · 2024Article
- Associations between regular physical exercise and physical, emotional, and cognitive health of older adults in China: an 8-year longitudinal study with propensity score matching.Frontiers in public health · 2024Article
- Hyperlipidemia and Cardiovascular Risk in Children and Adolescents.Biomedicines · 2023Review
- Promoting Physical Activity and Reducing Sedentary Behavior to Prevent Chronic Diseases during the COVID Pandemic and Beyond.Journal of clinical medicine · 2022Article
- Influence of Guideline Operationalization on Youth Activity Prevalence in the International Children's Accelerometry Database.Medicine and science in sports and exercise · 2022Article
- The relationship between occupational physical activity and dyslipidaemia in farmers with varying working modes in southwest China: the China multi-ethnic cohort study.BMC public health · 2022Article
- Trends and Risk Factors of Metabolic Syndrome among Korean Adolescents, 2007 to 2018.Diabetes & metabolism journal · 2021Article
- Treatment of Dyslipidaemia in Children.Biomedicines · 2021Review
- Agreement between the SHAPES Questionnaire and a Multiple-Sensor Monitor in Assessing Physical Activity of Adolescents Using Categorial Approach: A Cross-Sectional Study.Sensors (Basel, Switzerland) · 2021Article
- The effect of physical activity on quality of life and serum glucose and cholesterol levels in patients with congenital heart disease.American journal of cardiovascular disease · 2021Article
- Measuring Temporal Differences in Rural Canadian Children's Moderate-to-Vigorous Physical Activity.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe minimal and optimal amount of physical activity associated with cardiovascular health benefits in young people is unknown.
objectiveTo determine the dose-response relationship between moderate-to-vigorous physical activity (MVPA) with high-risk low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride values in youth.
methodsThe study sample consisted of 1235 adolescents (12 to 19 years of age) from the 20032004 and 20052006 cycles of the United States National Health and Nutrition Examination Survey. Objective measures of MVPA were obtained over seven days with accelerometers. LDL cholesterol, HDL cholesterol and triglycerides were measured from a fasting blood sample. High-risk values for these lipidslipoproteins were determined using age- and sex-specific thresholds. Logistic regression models were used to determine the dose-response relationships between MVPA and high-risk lipid levels.
resultsORs for high-risk HDL cholesterol and triglyceride values decreased in a curvilinear manner with increasing minutes of MVPA. Compared with no MVPA (0 min), the ORs for high-risk HDL cholesterol values at 15 min, 30 min and 60 min per day of MVPA were 0.29 (95% CI 0.13 to 0.67), 0.24 (95% CI 0.10 to 0.64) and 0.21 (95% CI 0.07 to 0.61), respectively. The corresponding ORs for high-risk triglyceride values were 0.40 (95% CI 0.18 to 0.76), 0.22 (95% CI 0.06 to 0.66) and 0.10 (95% CI 0.01 to 0.51). There was no discernible dose-response relationship between MVPA and LDL cholesterol.
conclusionsSmall amounts of MVPA were associated with a large reduction in the likelihood of having high-risk HDL cholesterol and triglyceride values in this representative sample of adolescents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.