ArticlePharmacognosy magazine2010
Natural products from the termite Nasutitermes corniger lowers aminoglycoside minimum inhibitory concentrations.
Article in Pharmacognosy magazine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Extraction, Characterization, and Antimicrobial Ability of Chitosan and Edible Oil From Ugandan Winged Termites.Food science & nutrition · 2025Article
- Thymoquinone' potent impairment of multidrug-resistant Staphylococcus aureus NorA efflux pump activity.Scientific reports · 2024Article
- Chemical Characterization and Antibacterial Properties ofJournal of lipids · 2022Article
- Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification.Journal of pharmaceutical analysis · 2020Review
- Antibacterial and antibiotic-modifying activities of fractions and compounds from Albizia adianthifolia against MDR Gram-negative enteric bacteria.BMC complementary and alternative medicine · 2019Article
- Vertebrates as a Bactericidal Agent.EcoHealth · 2018Article
- In vitro antibacterial and antibiotic modifying activity of crude extract, fractions and 3',4',7-trihydroxyflavone from Myristica fragrans Houtt against MDR Gram-negative enteric bacteria.BMC complementary and alternative medicine · 2018Article
- Antibacterial and Antibiotic-Modifying Activity of Methanol Extracts from Six Cameroonian Food Plants against Multidrug-Resistant Enteric Bacteria.BioMed research international · 2017Article
- Antibiotic resistance modulation by natural products obtained from Nasutitermes corniger (Motschulsky, 1855) and its nest.Saudi journal of biological sciences · 2015Article
- Edible and medicinal termites: a global overview.Journal of ethnobiology and ethnomedicine · 2015Review
- Antibiotic-potentiation activities of four Cameroonian dietary plants against multidrug-resistant Gram-negative bacteria expressing efflux pumps.BMC complementary and alternative medicine · 2014Article
- Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes.BMC research notes · 2012Article
- Natural products from ethnodirected studies: revisiting the ethnobiology of the zombie poison.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- 2012 - Another successful new year for Pharmacogn Mag.Pharmacognosy magazine · 2012Article
- The trade in medicinal animals in northeastern Brazil.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Evaluation of the Antimicrobial Activity of the Decoction of Tropidurus hispidus (Spix, 1825) and Tropidurus semitaeniatus (Spix, 1825) Used by the Traditional Medicine.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Antibacterial activities of selected Cameroonian spices and their synergistic effects with antibiotics against multidrug-resistant phenotypes.BMC complementary and alternative medicine · 2011Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial infectious agents present a risk to populations, as they are responsible for high morbidity and mortality. For combating these pathogens, our main line of defense is the use of antibiotics. However, indiscriminate use of these drugs develops resistant strains to these same drugs. The present study has tested the antibacterial and modifying antibiotic activity of natural products from Nasutitermes corniger (Termitidae) (Motschulsky), a termite used in folk medicine in Northeast Brazil, by the microdilution and checkerboard methods, respectively. In this study, the aqueous extract from the nest of N. corniger (ANCE) was prepared and tested with chlorpromazine (CPZ) for its antimicrobial activity, using the microdilution method. CPZ and ANCE were used independently and also in combination with aminoglycosides, against a strain of Escherichia coli resistant to these antibiotics, to determine the participation of efflux systems in resistance mechanisms. The fractional inhibitory concentration (FIC) index was calculated and evaluated for the occurrence of synergism, using the checkerboard method. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) values were >/= 2048 mug/mL for both strains of E. coli assayed, indicating low antibacterial activity. However, synergism was observed with kanamycin when the decoction was used, but when chlorpromazine was used, synergism was observed with kanamycin, amikacin, and neomycin. This synergism with CPZ indicated the involvement of an efflux system in the resistance to these aminoglycosides. Therefore, it was suggested that the natural products from N. corniger could be used as a source of zoo-derived natural products with kanamycin-modifying activity, resulting in a new approach against bacterial resistance to antibiotics.
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