ArticlePLoS computational biology2010
Enhancement of transport selectivity through nano-channels by non-specific competition.
Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic transport.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Flux through membrane channel: linear transportPhysical chemistry chemical physics : PCCP · 2025Article
- Kinetic cooperativity resolves bidirectional clogging within the nuclear pore complex.Biophysical journal · 2024Article
- Diameter dependence of transport through nuclear pore complex mimics studied using optical nanopores.eLife · 2024Article
- Counter-Intuitive Features of Particle Dynamics in Nanopores.International journal of molecular sciences · 2023Review
- Improving the hole picture: towards a consensus on the mechanism of nuclear transport.Biochemical Society transactions · 2023Article
- Percolation transition prescribes protein size-specific barrier to passive transport through the nuclear pore complex.Nature communications · 2022Article
- Nucleoporins' exclusive amino acid sequence features regulate their transient interaction with and selectivity of cargo complexes in the nuclear pore.Molecular biology of the cell · 2021Article
- Characterizing Binding Interactions That Are Essential for Selective Transport through the Nuclear Pore Complex.International journal of molecular sciences · 2021Article
- Physics of the Nuclear Pore Complex: Theory, Modeling and Experiment.Physics reports · 2021Article
- Impact of Interparticle Interaction on Thermodynamics of Nano-Channel Transport of Two Species.Entropy (Basel, Switzerland) · 2020Article
- Polarization Induced Electro-Functionalization of Pore Walls: A Contactless Technology.Biosensors · 2019Review
- Design principles of selective transport through biopolymer barriers.Physical review. E · 2019Article
- The Role of Cohesiveness in the Permeability of the Spatial Assemblies of FG Nucleoporins.Biophysical journal · 2019Article
- Protein Transport by the Nuclear Pore Complex: Simple Biophysics of a Complex Biomachine.Biophysical journal · 2017Review
- Article
- Diffusion of Charged Species in Liquids.Scientific reports · 2016Article
- Simple rules for passive diffusion through the nuclear pore complex.The Journal of cell biology · 2016Article
- The Multiple Faces of Disordered Nucleoporins.Journal of molecular biology · 2016Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The functioning of living cells requires efficient and selective transport of materials into and out of the cell, and between different cellular compartments. Much of this transport occurs through nano-scale channels that do not require large scale molecular re-arrangements (such as transition from a 'closed' to an 'open' state) and do not require a direct input of metabolic energy during transport. Nevertheless, these 'always open' channels are highly selective and pass only their cognate molecules, while efficiently excluding all others; indeed, these channels can efficiently transport specific molecules even in the presence of a vast excess of non-specific molecules. Such biological transporters have inspired the creation of artificial nano-channels. These channels can be used as nano-molecular sorters, and can also serve as testbeds for examining modes of biological transport. In this paper, we propose a simple kinetic mechanism that explains how the selectivity of such 'always open' channels can be based on the exclusion of non-specific molecules by specific ones, due to the competition for limited space inside the channel. The predictions of the theory account for the behavior of the nuclear pore complex and of artificial nanopores that mimic its function. This theory provides the basis for future work aimed at understanding the selectivity of various biological transport phenomena.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.