ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Cutaneous Adverse Events in the Randomized, Double-Blind, Active-Comparator DECIDE Study of Daclizumab High-Yield Process Versus Intramuscular Interferon Beta-1a in Relapsing-Remitting Multiple Sclerosis.Advances in therapy · 2016Trial
- Antiviral innate immunity and adaptive immune responses against monkeypox and viral immune evasion.World journal of virology · 2026Review
- Effective treatment of mogamulizumab-induced head and neck dermatitis with fluconazole in a patient with peripheral T-cell lymphoma.JAAD case reports · 2022Article
- Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion.Frontiers in immunology · 2020Review
- IL-1R Type 1-Deficient Mice Demonstrate an Impaired Host Immune Response against Cutaneous Vaccinia Virus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice.Immunology and cell biology · 2016Article
- Molecular characterization of human skin response to diphencyprone at peak and resolution phases: therapeutic insights.The Journal of investigative dermatology · 2014Article
- Chronic ethanol feeding induces subset loss and hyporesponsiveness in skin T cells.Alcoholism, clinical and experimental research · 2014Article
- Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation.Immunological reviews · 2014Review
- Organ-specific and memory treg cells: specificity, development, function, and maintenance.Frontiers in immunology · 2014Review
- IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.PLoS pathogens · 2013Article
- Disruption of TNF-α/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection.The Journal of investigative dermatology · 2012Article
- MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice.The Journal of clinical investigation · 2012Article
- Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity.Nature · 2012Article
- Advances in atopic dermatitis.Current opinion in immunology · 2011Review
- Smallpox vaccine safety is dependent on T cells and not B cells.The Journal of infectious diseases · 2011Article
- Phenotypical and functional specialization of FOXP3+ regulatory T cells.Nature reviews. Immunology · 2011Review
- Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
Individuals with atopic dermatitis immunized with the small pox vaccine, vaccinia virus (VV), are susceptible to eczema vaccinatum (EV), a potentially fatal disseminated infection. Dysfunction of Forkhead box P3 (FoxP3)-positive regulatory T cells (Treg) has been implicated in the pathogenesis of atopic dermatitis. To test whether Treg deficiency predisposes to EV, we percutaneously VV infected FoxP3-deficient (FoxP3(KO)) mice, which completely lack FoxP3(+) Treg. These animals generated both fewer VV-specific CD8(+) effector T cells and IFN-gamma-producing CD8(+) T cells than controls, had higher viral loads, and exhibited abnormal Th2-polarized responses to the virus. To focus on the consequences of Treg deficiency confined to the skin, we generated mixed CCR4(KO) FoxP3(KO) bone marrow (CCR4/FoxP3) chimeras in which skin, but not other tissues or central lymphoid organs, lack Treg. Like FoxP3(KO) mice, the chimeras had impaired VV-specific effector T cell responses and higher viral loads. Skin cytokine expression was significantly altered in infected chimeras compared with controls. Levels of the antiviral cytokines, type I and II IFNs and IL-12, were reduced, whereas expression of the proinflammatory cytokines, IL-6, IL-10, TGF-beta, and IL-23, was increased. Importantly, infection of CCR4/FoxP3 chimeras by a noncutaneous route (i.p.) induced immune responses comparable to controls. Our findings implicate allergic skin inflammation resulting from local Treg deficiency in the pathogenesis of EV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.