ArticleHypertension (Dallas, Tex. : 1979)2010
Endothelin activation of reactive oxygen species mediates stress-induced pressor response in Dahl salt-sensitive prehypertensive rats.
Article in Hypertension (Dallas, Tex. : 1979), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Effect of endothelin-1 on the blood pressure response to acute hypoxia and hyperoxia in healthy young men.Physiological reports · 2024Trial
- Endothelin receptor blockade blunts the pressor response to acute stress in men and women with obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Pathophysiological Mechanisms of Diabetes-Induced Macrovascular and Microvascular Complications: The Role of Oxidative Stress.Medical sciences (Basel, Switzerland) · 2025Review
- Endothelin Modulates Rhythm Disturbances and Autonomic Responses to Acute Emotional Stress in Rats.Biology · 2023Article
- Endothelin mediates sex-differences in acclimation to high salt diet in rats.Biology of sex differences · 2023Article
- Endothelin System and Ischemia-Induced Ventricular Tachyarrhythmias.Life (Basel, Switzerland) · 2022Review
- Impact of Non-Pharmacological Interventions on the Mechanisms of Atherosclerosis.International journal of molecular sciences · 2022Review
- Epididymal Fat-Derived Sympathoexcitatory Signals Exacerbate Neurogenic Hypertension in Obese Male Mice Exposed to Early Life Stress.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.Redox biology · 2020Review
- Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium-Derived Endothelin-1.Journal of the American Heart Association · 2018Article
- Maternal separation diminishes α-adrenergic receptor density and function in renal vasculature from male Wistar-Kyoto rats.American journal of physiology. Renal physiology · 2017Article
- Role of the endothelin system in sexual dimorphism in cardiovascular and renal diseases.Life sciences · 2016Review
- Angiotensin II is required to induce exaggerated salt sensitivity in Dahl rats exposed to maternal separation.Physiological reports · 2015Article
- High salt diet increases the pressor response to stress in female, but not male ETB-receptor-deficient rats.Physiological reports · 2015Article
- Effects of HIP in protection of HSP70 for stress-induced cardiomyocytes injury and its glucorticoid receptor pathway.Cell stress & chaperones · 2014Article
- 2013 Dahl Lecture: American Heart Association council for high blood pressure research clarifying the physiology of endothelin.Hypertension (Dallas, Tex. : 1979) · 2014Review
- Endothelin, kidney disease, and hypertension.Hypertension (Dallas, Tex. : 1979) · 2013Review
- Genetics of salt-sensitive hypertension.Current hypertension reports · 2011Review
- The mosaic theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension.Journal of the American Society of Hypertension : JASHReview
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Experiments were designed to test the hypothesis that endothelin (ET) and/or reactive oxygen species contribute to the pressor response induced by acute air jet stress in normotensive Dahl salt-sensitive rats maintained on a normal salt diet (prehypertensive). Mean arterial pressure was chronically monitored by telemetry before and after 3-day treatment with the free radical scavenger 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (Tempol) or ET receptor antagonists ABT-627 (ET A antagonist) or A-182086 (ET A/B antagonist) supplied in the drinking water. Rats were restrained and subjected to pulsatile air jet stress (3 minutes). Plasma samples at baseline and during acute stress were analyzed for 8-isoprostane (measure of reactive oxygen species production) and ET. Neither Tempol nor ET receptor antagonist treatment had an effect on baseline mean arterial pressure or plasma 8-isoprostane. The pressor response to acute stress was accompanied by significant increases in plasma 8-isoprostane and ET. Tempol significantly reduced both the total pressor response (area under the curve) and the stress-mediated increase in plasma 8-isoprostane; conversely, Tempol had no effect on the stress-induced increase in plasma ET. Combined ET(A/B) antagonism, but not selective ET(A) receptor blockade, similarly suppressed the pressor response to stress and stress-mediated rise in 8-isoprostane. Together these results indicate that reactive oxygen species contribute to the pressor response to acute air jet stress. Furthermore, the increase in reactive oxygen species occurs downstream of ET(B) receptor activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.