Trial reportPediatrics2010
Incidental findings on brain magnetic resonance imaging of children with sickle cell disease.
Trial report in Pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00072761 (Silent Cerebral Infarct Transfusion Multi-Center Clinical Trial), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Silent Cerebral Infarct Transfusion Multi-Center Clinical Trial
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.The Cochrane database of systematic reviews · 2020Pooled it
- Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.The Cochrane database of systematic reviews · 2017Pooled it
- Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.The Cochrane database of systematic reviews · 2013Pooled it
- Imaging review of sickle cell disease for the emergency radiologist.Emergency radiology · 2021Review
- Chronic pain in children: structural and resting-state functional brain imaging within a developmental perspective.Pediatric research · 2020Review
- Sleep-disordered breathing and comorbidities: role of the upper airway and craniofacial skeleton.Nature and science of sleep · 2020Review
- Isolated Propriospinal Myoclonus as a Presentation of Cervical Myelopathy.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Article
- Ethical framework for the detection, management and communication of incidental findings in imaging studies, building on an interview study of researchers' practices and perspectives.BMC medical ethics · 2017Article
- Spectrum of intracranial incidental findings on pediatric brain magnetic resonance imaging: What clinician should know?World journal of clinical pediatrics · 2016Review
- A novel, clinically relevant use of a piglet model to study the effects of anesthetics on the developing brain.Clinical and translational medicine · 2016Article
- Post-operative accidental diagnosis of intra-cerebellar astrocytoma in an emergency appendicectomy case.Indian journal of anaesthesia · 2016Article
- Neuroimaging findings in sickle cell disease.The British journal of radiology · 2014Review
- Children with congenital hypothyroidism have similar neuroradiological abnormal findings as healthy ones.TheScientificWorldJournal · 2013Article
- Neuroethical issues in clinical neuroscience research.Handbook of clinical neurology · 2013Review
- The impact of preparation and support procedures for children with sickle cell disease undergoing MRI.Pediatric radiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveWe describe the prevalence and range of incidental intracranial abnormalities identified through MRI of the brain in a large group of children screened for a clinical trial.
methodsWe included 953 children between 5 and 14 years of age who were screened with MRI of the brain for the Silent Infarct Transfusion Trial. All had sickle cell anemia or sickle beta-null thalassemia. MRI scans were interpreted by 3 neuroradiologists. MRI scans reported to have any abnormality were reviewed by 2 study neuroradiologists. Incidental findings were classified into 4 categories, that is, no, routine, urgent, or immediate referral recommended. Cerebral infarctions and vascular lesions were not considered incidental and were excluded.
resultsWe identified 63 children (6.6% [95% confidence interval: 5.1%-8.4%]) with 68 incidental intracranial MRI findings. Findings were classified as urgent in 6 cases (0.6%), routine in 25 cases (2.6%), and no referral required in 32 cases (3.4%). No children required immediate referral. Two children with urgent findings underwent surgery in the subsequent 6 months.
conclusionIn this large cohort of children, incidental intracranial findings were identified for 6.6%, with potentially serious or urgent findings for 0.6%.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.