ArticleThe Journal of pediatrics2010
Relationship between chronic transfusion therapy and body composition in subjects with thalassemia.
Article in The Journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07204015 (Body Composition in Pediatric Patients With Thalassemia Major Attending Assiut University Children's Hospital), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Body Composition in Pediatric Patients With Thalassemia Major Attending Assiut University Children's Hospital
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Thalassemia-associated osteoporosis: a systematic review on treatment and brief overview of the disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- Guidelines for the Standard Monitoring of Patients With Thalassemia: Report of the Thalassemia Longitudinal Cohort.Journal of pediatric hematology/oncology · 2015Guideline
- Osteoporosis in children and adolescents with transfusion-dependent thalassemia and the diagnostic value of different indicators.BMC pediatrics · 2026Article
- Cephalometric analysis of patients with beta thalassemia receiving fetal hemoglobin induction therapy.Journal of Taibah University Medical Sciences · 2024Article
- Prevalence and risk factors predisposing low bone mineral density in patients with thalassemia.Frontiers in endocrinology · 2024Article
- Association of osteoporosis and sarcopenia with fracture risk in transfusion-dependent thalassemia.Scientific reports · 2023Article
- Nutritional studies in patients with β-thalassemia major: A short review.Acta bio-medica : Atenei Parmensis · 2023Review
- Article
- Body Composition as a Predictor of Toxicity and Prognosis in Patients with Diffuse Large B-Cell Lymphoma Receiving R-CHOP Immunochemotherapy.Current oncology (Toronto, Ont.) · 2021Article
- The Trabecular Bone Score as a Predictor for Thalassemia-Induced Vertebral Fractures in Northeastern Thailand.Anemia · 2020Article
- Body Composition in Adult Patients with Thalassemia Major.International journal of endocrinology · 2016Article
- Anti-Thyroid Peroxidase Antibodies and Male Gender Are Associated with Diabetes Occurrence in Patients with Beta-Thalassemia Major.Journal of diabetes research · 2016Article
- The effect of gonadal status on body composition and bone mineral density in transfusion-dependent thalassemia.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Inadequate dietary intake in patients with thalassemia.Journal of the Academy of Nutrition and Dietetics · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveTo measure body composition in patients with thalassemia and explore its relationship to abnormal growth and bone mass. STUDY
designWe conducted a cross-sectional, multicenter study. Fat, lean, and bone mineral density (BMD) were assessed with dual-energy x-ray absorptiometry. Medical history, food frequency, and physical activity questionnaires were conducted in 257 transfused patients with thalassemia (age, 23.7+/-11 years [mean+/-SD]; 51% male) compared with 113 non-transfused patients (21.3+/-13 years; 44% male).
resultsSubjects with thalassemia were leaner compared with healthy American subjects from National Health and Nutrition Examination Survey III data. Transfused subjects had a higher percentage of body fat compared with non-transfused subjects after controlling for age, sex, and ethnicity; 11.8% of non-transfused pediatric subjects were considered underweight, significantly lower than National Health and Nutrition Examination Survey data (P=.03). Hemoglobin level was positively related to lean mass (P=.008). Body fat and lean mass were positive predictors for both height and BMD z-scores after adjustment for transfusion status, age, sex, ethnicity, calcium intake, and physical activity (all P<.001).
conclusionAlthough most adult patients with thalassemia had healthy body composition with rare obesity, young non-transfused patients appear at risk for being underweight. Optimizing physical activity and appropriate use of transfusion therapy may improve growth and bone health in these patients who are at-risk for being underweight.
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