ArticleNitric oxide : biology and chemistry2010
Differential roles of nitric oxide synthases in regulation of ultraviolet B light-induced apoptosis.
Article in Nitric oxide : biology and chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Generation of cellular reactive oxygen and nitrogen species by exposure to ultraviolet radiation.Biophysical reviews · 2025Review
- Post-exposure persistence of nitric oxide upregulation in skin cells irradiated by UV-A.Scientific reports · 2022Article
- Role of constitutive nitric oxide synthases in the dynamic regulation of the autophagy response of keratinocytes upon UVB exposure.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2020Article
- Weak Ultraviolet B Enhances the Mislocalization of Claudin-1 Mediated by Nitric Oxide and Peroxynitrite Production in Human Keratinocyte-Derived HaCaT Cells.International journal of molecular sciences · 2020Article
- The Effect of Endothelial Cells on UVB-induced DNA Damage and Transformation of Keratinocytes In 3D Polycaprolactone Scaffold Co-culture System.Photochemistry and photobiology · 2019Article
- Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats.Drug design, development and therapy · 2015Article
- The role of constitutive nitric-oxide synthase in ultraviolet B light-induced nuclear factor κB activity.The Journal of biological chemistry · 2014Article
- Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma.Antioxidants & redox signaling · 2013Article
- Variation in ultraviolet radiation and diabetes: evidence of an epigenetic effect that modulates diabetics' lifespan.Clinical epigenetics · 2013Article
- Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃.Molecular and cellular biochemistry · 2012Article
- Photo-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes.PloS one · 2012Article
- Protective Effect of Processed Panax ginseng, Sun Ginseng on UVB-irradiated Human Skin Keratinocyte and Human Dermal Fibroblast.Journal of ginseng research · 2012Article
- Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells.Mediators of inflammation · 2012Article
- The roles of Akt and NOSs in regulation of VLA-4-mediated melanoma cell adhesion to endothelial VCAM-1 after UVB-irradiation.Archives of biochemistry and biophysics · 2011Article
- Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation.Molecular vision · 2011Article
- ROS and p53 in regulation of UVB-induced HDM2 alternative splicing.Photochemistry and photobiologyArticle
- The role of constitutive nitric-oxide synthase in regulation of IKKα after ultraviolet irradiation.Photochemistry and photobiologyArticle
- Constitutive nitric oxide synthases deficiency impairs cyclobutane pyrimidine dimer repair following solar UV exposure in cells and mice.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ultraviolet B light (UVB) activates nitric oxide synthase(s) (NOSs) and nitric oxide (NO()) production, which plays a role in regulation of apoptosis. However, the role of NO() in UVB-induced apoptosis remains controversial. In this study, we analyzed expression and activation of constitutive NOSs (cNOSs) and their roles in UV-induced apoptosis of HaCaT keratinocytes. Our data showed that the expression of neuronal NOS (nNOS) was increased while endothelial NOS (eNOS) was uncoupled in the early phase (0-6 h) post-UVB. The expression of both cNOSs peaked at 12h post-UVB and NO() was transiently elevated with 30 min and then steadily rose from 6 to 18 h post-UVB. The expression of iNOS was detected at 6h post-UVB and then sturdily increased. Inhibition of cNOSs with L-NAME reduced the inducibility of NO(*) in the early and late phases of irradiation. Along with the eNOS uncoupling, an increased level of peroxynitrite (ONOO(-)) was detected in the early phase, but not in the late phase post-UVB. Inhibition of cNOSs reduced the production of ONOO(-) in the early time, but led to an increase of ONOO(-) in the late time after UVB-irradiation. The results indicate that cNOSs regulate NO()/ONOO(-) imbalance after UVB-irradiation. Our data suggested that the activation of cNOSs in the early phase post-UVB leads to NO()/ONOO(-) imbalance and promotes apoptosis via a caspase 3-independent pathway. The elevation of NO() in the late phase of UVB-irradiation is mainly produced by inducible NOS (iNOS). However, cNOSs also contribute to the NO() production and to maintain a higher NO()/ONOO(-) ratio, which reduces caspase 3 activity and protects cells from UVB-induced apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.