ArticleColloids and surfaces. B, Biointerfaces2010
Simple surface modification of a titanium alloy with silanated zwitterionic phosphorylcholine or sulfobetaine modifiers to reduce thrombogenicity.
Article in Colloids and surfaces. B, Biointerfaces, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 92 citations in OpenAlex.
- Antifouling Zwitterionic Polymer Coatings for Blood-Bearing Medical Devices.Langmuir : the ACS journal of surfaces and colloids · 2025Review
- Improving the hemocompatibility of a porohyperelastic layered vascular graft using luminal reversal microflows.Journal of the mechanical behavior of biomedical materials · 2024Article
- Rationale Design for Anchoring Pendant Groups of Zwitterionic Polymeric Medical Coatings.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Layer-by-Layer Coatings of Collagen-Hyaluronic acid Loaded with an Antibacterial Manuka Honey Bioactive Compound to Fight Metallic Implant Infections.ACS applied materials & interfaces · 2023Article
- Psoralen synergies with zinc implants to promote bone repair by regulating ZIP4 in rats with bone defect.Biomaterials research · 2023Article
- Bio-inspired hemocompatible surface modifications for biomedical applications.Progress in materials science · 2022Article
- A review on current research status of the surface modification of Zn-based biodegradable metals.Bioactive materials · 2022Review
- Influence of shear rate and surface chemistry on thrombus formation in micro-crevice.Journal of biomechanics · 2021Article
- Electrochemical and Biological Performance of Biodegradable Polymer Coatings on Ti6Al7Nb Alloy.Materials (Basel, Switzerland) · 2020Article
- Active wrinkles to drive self-cleaning: A strategy for anti-thrombotic surfaces for vascular grafts.Biomaterials · 2019Article
- Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2018Article
- Impact of Anti-Biofouling Surface Coatings on the Properties of Nanomaterials and Their Biomedical Applications.Journal of materials chemistry. B · 2018Article
- Visualization and analysis of biomaterial-centered thrombus formation within a defined crevice under flow.Biomaterials · 2016Article
- Real time visualization and characterization of platelet deposition under flow onto clinically relevant opaque surfaces.Journal of biomedical materials research. Part A · 2015Article
- Comprehensive genetic analysis of early host body reactions to the bioactive and bio-inert porous scaffolds.PloS one · 2014Article
- Article
- Fabrication and in vitro evaluation of stable collagen/hyaluronic acid biomimetic multilayer on titanium coatings.Journal of the Royal Society, Interface · 2013Article
- Surface modification of a biodegradable magnesium alloy with phosphorylcholine (PC) and sulfobetaine (SB) functional macromolecules for reduced thrombogenicity and acute corrosion resistance.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- Improvement in endothelial cell adhesion and retention under physiological shear stress using a laminin-apatite composite layer on titanium.Journal of the Royal Society, Interface · 2013Article
- Immobilized Carbonic Anhydrase on Hollow Fiber Membranes Accelerates CO(2) Removal from Blood.Journal of membrane science · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Thrombosis and thromboembolism remain problematic for a large number of blood contacting medical devices and limit broader application of some technologies due to this surface bioincompatibility. In this study we focused on the covalent attachment of zwitterionic phosphorylcholine (PC) or sulfobetaine (SB) moieties onto a TiAl(6)V(4) surface with a single step modification method to obtain a stable blood compatible interface. Silanated PC or SB modifiers (PCSi or SBSi) which contain an alkoxy silane group and either PC or SB groups were prepared respectively from trimethoxysilane and 2-methacryloyloxyethyl phosphorylcholine (MPC) or N-(3-sulfopropyl)-N-(methacryloxyethyl)-N,N-dimethylammonium betaine (SMDAB) monomers by a hydrosilylation reaction. A cleaned and oxidized TiAl(6)V(4) surface was then modified with the PCSi or SBSi modifiers by a simple surface silanization reaction. The surface was assessed with X-ray photoelectron spectroscopy (XPS), attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) and contact angle goniometry. Platelet deposition and bulk phase activation were evaluated following contact with anticoagulated ovine blood. XPS results verified successful modification of the PCSi or SBSi modifiers onto TiAl(6)V(4) based on increases in surface phosphorous or sulfur respectively. Surface contact angles in water decreased with the addition of hydrophilic PC or SB moieties. Both the PCSi and SBSi modified TiAl(6)V(4) surfaces showed decreased platelet deposition and bulk phase platelet activation compared to unmodified TiAl(6)V(4) and control surfaces. This single step modification with PCSi or SBSi modifiers offers promise for improving the surface hemocompatibility of TiAl(6)V(4) and is attractive for its ease of application to geometrically complex metallic blood contacting devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.