ReviewPharmacology & therapeutics2010
The application of drug dose equivalence in the quantitative analysis of receptor occupation and drug combinations.
Review in Pharmacology & therapeutics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Synergistic transition from type-I-like to type-II-like symptomology in a pyrethroid mixture and its impact on knockdown-mortality relationships in Musca domestica L.Pest management science · 2026Article
- Mesenchymal stem cell membrane-coated nanoconstructs: why have they not yet found a home in clinical practice?Nanomedicine (London, England) · 2024Article
- Combined Treatment of Dendrosomal-Curcumin and Daunorubicin Synergistically Inhibit Cell Proliferation, Migration and Induce Apoptosis in A549 Lung Cancer Cells.Advanced pharmaceutical bulletin · 2023Article
- Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966.Frontiers in pharmacology · 2022Article
- In Vitro Combinations of Baloxavir Acid and Other Inhibitors against Seasonal Influenza A Viruses.Viruses · 2020Article
- Synergistic antidepressant-like effect of capsaicin and citalopram reduces the side effects of citalopram on anxiety and working memory in rats.Psychopharmacology · 2020Article
- Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model.Pharmacology research & perspectives · 2018Article
- Reinforcing Effects of Binary Mixtures of Common Bath Salt Constituents: Studies with 3,4-Methylenedioxypyrovalerone (MDPV), 3,4-Methylenedioxymethcathinone (methylone), and Caffeine in Rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Searching Synergistic Dose Combinations for Anticancer Drugs.Frontiers in pharmacology · 2018Review
- Method to Assess Interactivity of Drugs with Nonparallel Concentration Effect Relationships.Current cancer drug targets · 2017Article
- Discriminative Stimulus Effects of Binary Drug Mixtures: Studies with Cocaine, MDPV, and Caffeine.The Journal of pharmacology and experimental therapeutics · 2016Article
- Opioid and cannabinoid synergy in a mouse neuropathic pain model.British journal of pharmacology · 2016Article
- Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test.European journal of pharmacology · 2016Article
- Drug Combinations: Tests and Analysis with Isoboles.Current protocols in pharmacology · 2016Article
- Ethanol and cocaine: environmental place conditioning, stereotypy, and synergism in planarians.Alcohol (Fayetteville, N.Y.) · 2014Article
- Methylphenidate and impulsivity: a comparison of effects of methylphenidate enantiomers on delay discounting in rats.Psychopharmacology · 2014Article
- Cocaine synergism with α agonists in rat aorta: computational analysis reveals an action beyond reuptake inhibition.Drug and alcohol dependence · 2013Article
- Additive feeding inhibitory and aversive effects of naltrexone and exendin-4 combinations.International journal of obesity (2005) · 2013Article
- Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity.Scientific reports · 2013Article
- Revisiting the isobole and related quantitative methods for assessing drug synergism.The Journal of pharmacology and experimental therapeutics · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In this review we show that the concept of dose equivalence for two drugs, the theoretical basis of the isobologram, has a wider use in the analysis of pharmacological data derived from single and combination drug use. In both its application to drug combination analysis with isoboles and certain other actions, listed below, the determination of doses, or receptor occupancies, that yield equal effects provide useful metrics that can be used to obtain quantitative information on drug actions without postulating any intimate mechanism of action. These other drug actions discussed here include (1) combinations of agonists that produce opposite effects, (2) analysis of inverted U-shaped dose-effect curves of single agents, (3) analysis on the effect scale as an alternative to isoboles and (4) the use of occupation isoboles to examine competitive antagonism in the dual receptor case. New formulas derived to assess the statistical variance for additive combinations are included, and the more detailed mathematical topics are included in the Appendix.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.