ArticleVirology journal2010
Recombination analysis reveals a double recombination event in hepatitis E virus.
Article in Virology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- ORF2 of hepatitis E virus: genetic and antigenic variation across genotypes and implications for immunity, diagnostics and vaccine development.The Journal of general virology · 2026Review
- Detection and Whole Genome Amplification of the 4d Type of Porcine Hepatitis E Virus in Eastern Tibet, China.Veterinary medicine and science · 2025Article
- Current knowledge on the epidemiology and detection methods of hepatitis E virus in China.Virology journal · 2024Review
- Genetic Evolution of Hepatitis E Virus.Advances in experimental medicine and biology · 2023Review
- Advanced sequencing approaches detected insertions of viral and human origin in the viral genome of chronic hepatitis E virus patients.Scientific reports · 2022Article
- Update: proposed reference sequences for subtypes of hepatitis E virus (speciesThe Journal of general virology · 2020Article
- Identification of a putative novel genotype 3/rabbit hepatitis E virus (HEV) recombinant.PloS one · 2018Article
- Genotype-Specific Evolution of Hepatitis E Virus.Journal of virology · 2017Article
- Hepatitis E Virus Mutations: Functional and Clinical Relevance.EBioMedicine · 2016Review
- Variability and pathogenicity of hepatitis E virus genotype 3 variants.The Journal of general virology · 2015Article
- Intergenic incompatibilities reduce fitness in hybrids of extremely closely related bacteriophages.PeerJ · 2015Article
- Consensus proposals for classification of the family Hepeviridae.The Journal of general virology · 2014Article
- Novel hepatitis E like virus found in Swedish moose.The Journal of general virology · 2014Article
- Article
- The adaptive potential of hybridization demonstrated with bacteriophages.Journal of molecular evolution · 2013Article
- Genetic variability and the classification of hepatitis E virus.Journal of virology · 2013Article
- Hepatitis E virus mixed infection in immunocompetent patient.Emerging infectious diseases · 2013Article
- Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination.Journal of virology · 2012Article
- Molecular virology of hepatitis E virus.Virus research · 2011Review
- Novel hepatitis E virus genotype in Norway rats, Germany.Emerging infectious diseases · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination of Hepatitis E Virus (HEV) has rarely been reported. In the present study, phylogenetic and recombination analyses were performed on 134 complete HEV genomes. Three potentially significant recombination events, including both intra-genotype and one inter-genotype, were identified by recombination detection analysis. Recombination events I and II occurred intra-genotype and inter-genotype, respectively, among three isolates, including the lineage represented by CHN-XJ-SW13 (GU119961, swine isolate), E067-SIJ05C (AB369690, human isolate), and JJT-Kan (AB091394, human isolate), and lead to the recombinant swine isolate swCH31 (DQ450072). Recombination event III occurred between the lineage represented by the NA1 (M73218) and K52-87 (L25595), which resulted in the recombinant Xingjiang-1 (D11092). Our analyses proved that that recombination could occur between human and swine HEV strains, double recombination events existed in HEV, and recombination event could happen within ORF2 region of HEV. These results will provide valuable hints for future research on HEV diversity.
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