ArticleBMC evolutionary biology2010
Evidence for an early evolutionary emergence of gamma-type carbonic anhydrases as components of mitochondrial respiratory complex I.
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Limited functional compensation among subunits of the carbonic anhydrase module of mitochondrial complex I.Planta · 2026Article
- Review
- Comparative Genomics of Chloropicon primus and Chloropicon roscoffensis Provide Insights into the Evolutionary Dynamics and Ecological Success of These Tiny Green Algae in Marine Environments.Genome biology and evolution · 2025Article
- Plant supercomplex I + III2 structure and function: implications for the growing field.Biochemical Society transactions · 2024Review
- Using cryo-EM to understand the assembly pathway of respiratory complex I.Acta crystallographica. Section D, Structural biology · 2024Article
- Novel Drug Screening Assay forJournal of medicinal chemistry · 2024Article
- Functional and biochemical characterization of the Toxoplasma gondii succinate dehydrogenase complex.PLoS pathogens · 2023Article
- Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes.Biological reviews of the Cambridge Philosophical Society · 2023Article
- The biogenesis and regulation of the plant oxidative phosphorylation system.Plant physiology · 2023Review
- Conformational changes in mitochondrial complex I of the thermophilic eukaryoteScience advances · 2022Article
- A ferredoxin bridge connects the two arms of plant mitochondrial complex I.The Plant cell · 2021Article
- Photosynthesis of the Cyanidioschyzon merolae cells in blue, red, and white light.Photosynthesis research · 2021Article
- Specific features and assembly of the plant mitochondrial complex I revealed by cryo-EM.Nature communications · 2020Article
- Article
- Respiratory chain Complex I of unparalleled divergence in diplonemids.The Journal of biological chemistry · 2018Article
- The atypical subunit composition of respiratory complexes I and IV is associated with original extra structural domains in Euglena gracilis.Scientific reports · 2018Article
- SDH6 and SDH7 Contribute to Anchoring Succinate Dehydrogenase to the Inner Mitochondrial Membrane in Arabidopsis thaliana.Plant physiology · 2017Article
- The CA domain of the respiratory complex I is required for normal embryogenesis in Arabidopsis thaliana.Journal of experimental botany · 2016Article
- Data showing the compositional complexity of the mitochondrial proteome of a unicellular eukaryote (Acanthamoeba castellanii, supergroup Amoebozoa).Data in brief · 2014Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe complexity of mitochondrial complex I (CI; NADH:ubiquinone oxidoreductase) has increased considerably relative to the homologous complex in bacteria. Comparative analyses of CI composition in animals, fungi and land plants/green algae suggest that novel components of mitochondrial CI include a set of 18 proteins common to all eukaryotes and a variable number of lineage-specific subunits. In plants and green algae, several purportedly plant-specific proteins homologous to gamma-type carbonic anhydrases (gammaCA) have been identified as components of CI. However, relatively little is known about CI composition in the unicellular protists, the characterizations of which are essential to our understanding of CI evolution.
resultsWe have performed a tandem mass spectrometric characterization of CI from the amoeboid protozoon Acanthamoeba castellanii. Among the proteins identified were two gammaCA homologs, AcCa1 and AcCa2, demonstrating that gammaCA proteins are not specific to plants/green algae. In fact, through bioinformatics searches we detected gammaCA homologs in diverse protist lineages, and several of these homologs are predicted to possess N-terminal mitochondrial targeting peptides.
conclusionsThe detection of gammaCAs in CI of Acanthamoeba, considered to be a closer relative of animals and fungi than plants, suggests that gammaCA proteins may have been an ancestral feature of mitochondrial CI, rather than a novel, plant-specific addition. This assertion is supported by the presence of genes encoding gammaCAs in the nuclear genomes of a wide variety of eukaryotes. Together, these findings emphasize the importance of a phylogenetically broad characterization of CI for elucidating CI evolution in eukaryotes.
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