ArticleCell proliferation2010
Cell proliferation and cell cycle alterations in oesophageal p53-mutated cancer cells treated with cisplatin in combination with photodynamic therapy.
Article in Cell proliferation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- EXPRESSION OF CONCERN: Cell Proliferation and Cell Cycle Alterations in Oesophageal p53-Mutated Cancer Cells Treated With Cisplatin in Combination With Photodynamic Therapy.Cell proliferation · 2026Article
- Veratramine influences the proliferation of human osteosarcoma cells through modulating the PI3K/AKT signaling cascade.Genes & diseases · 2026Article
- Nanodynamic therapy for cancer: mechanistic innovations, targeting strategies and multimodal treatments.Journal of translational medicine · 2025Review
- Combined Photodynamic Therapy and Chemotherapy Using Local Intra-Arterial Intratumoral Administration of Chlorin e6 and Cisplatin: First Clinical Observations.International journal of molecular sciences · 2025Article
- Photodynamic therapy in oral cancer: a review of clinical studies.Medical oncology (Northwood, London, England) · 2023Review
- Photodynamic therapy induced cell cycle arrest and cancer cell synchronization: review.Frontiers in oncology · 2023Review
- Application of Monolayer Cell Cultures for Investigating Basic Mechanisms of Photodynamic Therapy.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells.International journal of molecular medicine · 2021Article
- Evaluation for Synergistic Effects by Combinations of Photodynamic Therapy (PDT) with Temoporfin (mTHPC) and Pt(II) Complexes Carboplatin, Cisplatin or Oxaliplatin in a Set of Five Human Cancer Cell Lines.International journal of molecular sciences · 2018Article
- Article
- Effects of combination of melatonin and laser irradiation on ovarian cancer cells and endothelial lineage viability.Lasers in medical science · 2016Article
- Prospects in the Application of Photodynamic Therapy in Oral Cancer and Premalignant Lesions.Cancers · 2016Review
- Altered gene transcription in human cells treated with Ludox® silica nanoparticles.International journal of environmental research and public health · 2014Article
- Carboplatin synergistically triggers the efficacy of photodynamic therapy via caspase 3-, 8-, and 12-dependent pathways in human anaplastic thyroid cancer cells.Lasers in medical science · 2014Article
- Overexpression of RBBP6, alone or combined with mutant TP53, is predictive of poor prognosis in colon cancer.PloS one · 2013Article
- The toxicity outcome of silica nanoparticles (Ludox®) is influenced by testing techniques and treatment modalities.Analytical and bioanalytical chemistry · 2012Article
- Enhancing photodynamyc therapy efficacy by combination therapy: dated, current and oncoming strategies.Cancers · 2011Article
- Targets and mechanisms of photodynamic therapy in lung cancer cells: a brief overview.Cancers · 2011Article
Corrections and comments
- Expression of concern
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe major goal of anti-cancer therapies is selective destruction of tumour cells with minimum side effects on normal cells. Towards this aim, combination of different therapeutic modalities has been evaluated for improving control of neoplastic diseases and quality of life for the patient. Photodynamic therapy (PDT) is a procedure for treatment of various types of cancer, but its combination with other established treatments has not been evaluated in detail. We have used KYSE-510 cells from a human oesophageal carcinoma as an in vitro model to investigate whether cisplatin (CDDP) could be combined with PDT to increase cell death with respect to single treatments. MATERIALS AND
methodsp53-mutated KYSE-510 cells were treated with CDDP alone or in combination with PDT. Analyses of cell viability, cell cycle progression and apoptosis induction were carried out at specific times after treatments.
resultsDecrease in cell viability, cell cycle arrest at the G(2)/M- and S-phases boundary, and apoptosis induction were observed after single and combined treatments.
conclusionsOur results show that low CDDP doses (0.25-1 microm) induce cell mortality and cell cycle perturbation, which were more evident when given in combination with PDT, but in contrast to work of other authors no synergistic activity was found. Apoptosis occurred via intrinsic pathways in treated cells, although it did not represent the predominant mode of cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.