ArticleClinical physiology and functional imaging2010
Elevated augmentation index derived from peripheral arterial tonometry is associated with abnormal ventricular-vascular coupling.
Article in Clinical physiology and functional imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
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- The effects of exercise training on vascular function among overweight adults with obstructive sleep apnea.Translational sports medicine · 2021Article
- Association of particles of lipoprotein subclasses with arterial stiffness in a high-risk working population: the Baptist Employee Healthy Heart Study (BEHHS).The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2020Article
- Racial Differences in Left Ventricular Mass and Wave Reflection Intensity in Children.Frontiers in pediatrics · 2020Article
- Menstrual phase and the vascular response to acute resistance exercise.European journal of applied physiology · 2018Article
- Central wave reflection is associated with peripheral arterial resistance in addition to arterial stiffness in subjects without antihypertensive medication.BMC cardiovascular disorders · 2016Article
- Influence of vascular function and pulsatile hemodynamics on cardiac function.Current hypertension reports · 2015Review
- Effects of exercise and weight loss in older adults with obstructive sleep apnea.Medicine and science in sports and exercise · 2015Article
- Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease.BMC nephrology · 2013Article
- Racial differences in arterial stiffness and microcirculatory function between Black and White Americans.Journal of the American Heart Association · 2013Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundAlthough typically derived from the contour of arterial pressure waveform, augmentation index (AIx) may also be derived from the digital pulse volume waveform using finger plethysmography (peripheral arterial tonometry, PAT). Little is known regarding the physiologic correlates of AIx derived from PAT. In this study, we investigated the relation of PAT-AIx with measures of ventricular-vascular coupling.
methodsPulse volume waves were measured via PAT and used to derive AIx. Using 2-dimensional echocardiography, effective arterial elastance index (EaI) was estimated as end-systolic pressure/stroke volume index. Left ventricular (LV) end-systolic elastance index (E(LV)I) was calculated as end-systolic pressure/end-systolic volume index. Ventricular-vascular coupling ratio was defined as EaI/E(LV)I.
resultsGiven the bi-directional nature of ventricular-vascular uncoupling as measured by echocardiography, patients were separated into three groups: low EaI/E(LV)I (<0.6, n = 21), optimal EaI/E(LV)I (mean 0.6-1.2, n = 16) and high EaI/E(LV)I (>1.2, n = 10). Adjusting for potential confounders (age, mean arterial pressure, height and heart rate), patients with optimal EaI/E(LV)I had lower AIx (1 +/- 4%, P<0.05) compared to those with low EaI/E(LV)I (13 +/- 4%) and high EaI/E(LV)I (19 +/- 5%).
conclusionsAbnormal ventricular-vascular coupling, arising from either increased effective arterial elastance or increased ventricular elastance, is associated with increased AIx as measured by PAT. Additional research is needed to examine other vascular correlates of PAT-AIx.
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