ReviewCurrent drug targets2010
Hedgehog signaling in the normal and neoplastic mammary gland.
Review in Current drug targets, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- piRNAs as Potential Regulators of Mammary Gland Development and Pathology in Livestock.Veterinary sciences · 2025Review
- Novel Anti-Cancer Stem Cell Compounds: A Comprehensive Review.Pharmaceutics · 2024Review
- Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas.BMC veterinary research · 2023Article
- Asymmetric cell division of mammary stem cells.Cell division · 2021Review
- Two Sides of the Same Coin: The Role of Developmental pathways and pluripotency factors in normal mammary stem cells and breast cancer metastasis.Journal of mammary gland biology and neoplasia · 2020Review
- Microarray and pathway analysis of two COMMA-Dβ derived clones reveal important differences relevant to their developmental capacityOncotarget · 2019Article
- EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells.Nature communications · 2017Article
- In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.Oncotarget · 2016Article
- Normal mammary development and function in mice with Ift88 deleted in MMTV- and K14-Cre expressing cells.Cilia · 2014Article
- Regulation of angiogenesis via Notch signaling in breast cancer and cancer stem cells.Biochimica et biophysica acta · 2013Review
- An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18 expression in breast papillomas and papillary carcinomas.Diagnostic pathology · 2013Article
- Skp2 is a promising therapeutic target in breast cancer.Frontiers in oncology · 2012Article
- Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened.Developmental biology · 2011Article
- Role of Notch and its oncogenic signaling crosstalk in breast cancer.Biochimica et biophysica acta · 2011Review
- TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling.Cancer research · 2011Article
- Shared signaling pathways in normal and breast cancer stem cells.Journal of carcinogenesis · 2011Article
- Mammary gland development.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The hedgehog signal transduction network is a critical regulator of metazoan development. Inappropriate activation of this network is implicated in several different cancers, including breast. Genetic evidence in mice as well as molecular biological studies in human cells clearly indicate that activated signaling can lead to mammary hyperplasia and, in some cases, tumor formation. However, the exact role(s) activated hedgehog signaling plays in the development or progression of breast cancer also remain unclear. In this review, we have discussed recent data regarding the mechanism(s) by which the hedgehog network may signal in the mammary gland, as well as the data implicating activated signaling as a contributing factor to breast cancer development. Finally, we provide a brief update on the available hedgehog signaling inhibitors with respect to ongoing clinical trials, some of which will include locally advanced or metastatic breast cancers. Given the growing intensity with which the hedgehog signaling network is being studied in the normal and neoplastic mammary gland, a more complete understanding of this network should allow more effective targeting of its activities in breast cancer treatment or prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.