Evidence map›Paper›PMID 20544946›Full record

ArticleMuscle & nerve2010

Effect of prior exercise on thermal sensitivity of malignant hyperthermia-susceptible muscle.

Benjamin T Corona, Susan L Hamilton, Christopher P Ingalls

Abstract read
In one paragraph

Article in Muscle & nerve, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Malignant hyperthermia: a review.Orphanet journal of rare diseases · 2015
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benjamin T CoronaDepartment of Kinesiology & Health, PO Box 3975, Georgia State University, Atlanta, Georgia 30302-3975, USA.
Susan L Hamilton
Christopher P Ingalls

Funding

Basis of Muscle Dysfunction in Malignant Hyperthermia & Central Core DiseaseR01AR053349 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DIRKSEN, ROBERT T, HAMILTON, SUSAN L · 2006 to 2020
$8.0M
MODULATION OF SARCOPLASMIC RETICULUM CALCIUM RELEASER01AR041802 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI HAMILTON, SUSAN L, INGALLS, CHRISTOPHER · 1993 to 2014
$5.6M
NIAMS NIH HHS AR-41802NIAMS NIH HHS R01 AR041802NIAMS NIH HHS R01 AR053349
6 · The paper itself

Abstract

Malignant hyperthermia (MH) episodes may occur upon exposure to halogenated anesthetics, during resistance and endurance exercise, and in response to thermal stress. The purpose of this study was to investigate the effects of prior eccentric and concentric (i.e., wheel running) exercise on the thermal sensitivity of isolated MH-susceptible mouse muscle (RyR1(Y522S/wt)). Eccentric, but not concentric, exercise attenuated the thermal sensitivity of MH-susceptible muscle.

Indexed as

Muscle ContractionPhysical Conditioning, AnimalAnalysis of VarianceAnimalsDisease SusceptibilityMalignant HyperthermiaMiceMice, TransgenicMuscle, Skeletal

Identifiers

PMID20544946
PMCPMC2980915

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.