ReviewEnvironmental and molecular mutagenesis2010
The mitochondrial proteome: a dynamic functional program in tissues and disease states.
Review in Environmental and molecular mutagenesis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets.The EMBO journal · 2026Article
- Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells.Biological research · 2023Article
- Mitochondrial Fission Protein 1: Emerging Roles in Organellar Form and Function in Health and Disease.Frontiers in endocrinology · 2021Review
- Fyn kinase regulates translation in mammalian mitochondria.Biochimica et biophysica acta. General subjects · 2017Article
- Spatial and temporal dynamics of the cardiac mitochondrial proteome.Expert review of proteomics · 2015Review
- Mitochondrial targets for pharmacological intervention in human disease.Journal of proteome research · 2015Review
- Role of soluble adenylyl cyclase in mitochondria.Biochimica et biophysica acta · 2014Review
- The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility.Reproductive biology and endocrinology : RB&E · 2014Review
- Characterization, design, and function of the mitochondrial proteome: from organs to organisms.Journal of proteome research · 2014Article
- The role of mitochondria from mature oocyte to viable blastocyst.Obstetrics and gynecology international · 2013Article
- Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation.The Journal of general physiology · 2012Article
- Article
- Isolation of functional mitochondria from rat kidney and skeletal muscle without manual homogenization.Analytical biochemistry · 2011Article
- Alteration of mitochondrial function in adult rat offspring of malnourished dams.World journal of diabetes · 2011Article
- Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation.Cell metabolism · 2011Article
- Taking pressure off the heart: the ins and outs of atrophic remodelling.Cardiovascular research · 2011Review
- Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule.American journal of physiology. Cell physiology · 2011Article
- Computational modeling of mitochondrial energy transduction.Critical reviews in biomedical engineering · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The nuclear DNA transcriptional programming of the mitochondria proteome varies dramatically between tissues depending on its functional requirements. This programming generally regulates all of the proteins associated with a metabolic or biosynthetic pathway associated with a given function, essentially regulating the maximum rate of the pathway while keeping the enzymes at the same molar ratio. This may permit the same regulatory mechanisms to function at low- and high-flux capacity situations. This alteration in total protein content results in rather dramatic changes in the mitochondria proteome between tissues. A tissues mitochondria proteome also changes with disease state, in Type 1 diabetes the liver mitochondrial proteome shifts to support ATP production, urea synthesis, and fatty acid oxidation. Acute flux regulation is modulated by numerous posttranslational events that also are highly variable between tissues. The most studied posttranslational modification is protein phosphorylation, which is found all of the complexes of oxidative phosphorylation and most of the major metabolic pathways. The functional significance of these modifications is currently a major area of research along with the kinase and phosphatase regulatory network. This near ubiquitous presence of protein phosphorylations, and other posttranslational events, in the matrix suggest that not all posttranslational events have functional significance. Screening methods are being introduced to detect the active or dynamic posttranslational sites to focus attention on sites that might provide insight into regulatory mechanisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.