ArticleImmunogenetics2010
The complete inventory of receptors encoded by the rat natural killer cell gene complex.
Article in Immunogenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Secondary Immune Surveillance via upregulation of C-type lectin receptors.Npj gut and liver · 2026Article
- Recognition ofInnate immunity · 2023Review
- C-Type Lectin-Like Receptors As Emerging Orchestrators of Sterile Inflammation Represent Potential Therapeutic Targets.Frontiers in immunology · 2018Review
- The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation.Immunogenetics · 2017Article
- Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses.Blood advances · 2017Article
- The evolution of natural killer cell receptors.Immunogenetics · 2016Review
- The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state.European journal of immunology · 2015Article
- Dedicated immunosensing of the mouse intestinal epithelium facilitated by a pair of genetically coupled lectin-like receptors.Mucosal immunology · 2015Article
- The c.503T>C Polymorphism in the Human KLRB1 Gene Alters Ligand Binding and Inhibitory Potential of CD161 Molecules.PloS one · 2015Article
- Complexity and Diversity of the NKR-P1:Clr (Klrb1:Clec2) Recognition Systems.Frontiers in immunology · 2014Review
- Identification of a chicken CLEC-2 homologue, an activating C-type lectin expressed by thrombocytes.Immunogenetics · 2012Article
- Article
- Evolution of the C-type lectin-like receptor genes of the DECTIN-1 cluster in the NK gene complex.TheScientificWorldJournal · 2012Review
- Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains.Immunogenetics · 2011Article
- Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse.Immunogenetics · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The natural killer cell gene complex (NKC) encodes receptors belonging to the C-type lectin superfamily expressed primarily by NK cells and other leukocytes. In the rat, the chromosomal region that starts with the Nkrp1a locus and ends with the Ly49i8 locus is predicted to contain 67 group V C-type lectin superfamily genes, making it one of the largest congregation of paralogous genes in vertebrates. Based on physical proximity and phylogenetic relationships between these genes, the rat NKC can be divided into four major parts. We have previously reported the cDNA cloning of the majority of the genes belonging to the centromeric Nkrp1/Clr cluster and the two telomeric groups, the Klre1-Klri2 and the Ly49 clusters. Here, we close the gap between the Nkrp1/Clr and the Klre1-Klri2 clusters by presenting the cDNA cloning and transcription patterns of eight genes spanning from Cd69 to Dectin1, including the novel Clec2m gene. The definition, organization, and evolution of the rat NKC are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.