SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2010
A systematic review of orofacial pain in patients receiving cancer therapy.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- The influence of pediatric cancer treatment on taste perception and food hedonics: a systematic review.Nutrition reviews · 2024Pooled it
- Prevalence of orofacial and head pain: an umbrella review of systematic reviews.Journal of oral & facial pain and headache · 2024Pooled it
- A randomised controlled trial of clinical pharmacy intervention versus standard care to improve medication adherence in outpatients with head and neck cancer receiving radiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Trial
- Treatment-related pain in refractory cancer pain: prevalence, mechanisms, and clinical implications in a tertiary referral cohort.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Cancer-related pain in head and neck cancer survivors: longitudinal findings from the Head and Neck 5000 clinical cohort.Journal of cancer survivorship : research and practice · 2025Article
- Chronic Oral Complications of Oral Cancer Therapy.Dental clinics of North America · 2025Review
- Mechanisms for Orofacial Pain: Roles of Immunomodulation, Metabolic Reprogramming, Oxidative Stress and Epigenetic Regulation.Biomedicines · 2025Review
- Health-related quality of life assessment in head and neck cancer: A systematic review of phase II and III clinical trials.Heliyon · 2024Article
- Prevalence and risk factors of chronic oral complications in head and neck cancer therapies: A retrospective study.Medicina oral, patologia oral y cirugia bucal · 2024Observational
- Knowledge about dental care in patients with head and neck cancer among senior dental school students: a cross-sectional descriptive study.BMC medical education · 2024Article
- Quality of life, craniomandibular function, and psychosocial factors related to pain and movement in patients with head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Review
- Facial pain, health-related quality of life and trismus-related symptoms up to 5 years post-radiotherapy for head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Psychological variables associated with quality of life in patients with head and neck cancer: the role of body image distress.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Head and neck cancer survivors' pain in France: the VICAN study.Journal of cancer survivorship : research and practice · 2022Article
- Orofacial Pain and Snoring/Obstructive Sleep Apnea in Individuals with Head and Neck Cancer: A Critical Review.Journal of oral & facial pain and headache · 2022Review
- Dental Evaluation Prior to Cancer Therapy.Frontiers in oral health · 2022Review
- Glia and Orofacial Pain: Progress and Future Directions.International journal of molecular sciences · 2021Review
- TNFα promotes oral cancer growth, pain, and Schwann cell activation.Scientific reports · 2021Article
- Factors associated with unintentional weight loss among older adults in a geriatric outpatient clinic of university hospital.PloS one · 2021Article
Corrections and comments
- Erratum issuedOberlee-Edwards, Lorree [corrected to Oberle-Edwards, Loree]
Authors and funding
12 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe present the findings of a structured systematic review of the literature assessing orofacial pain induced by malignant disease and/or its therapy (excluding mucositis). This evaluation of the literature published after the 1989 NIH Development Consensus conference on the oral complications of cancer therapies is an effort to assess the prevalence of pain, quality of life and economic impact, and management strategies for cancer therapy-induced orofacial pain.
methodsA systematic medical literature search was conducted with assistance from a research librarian in MEDLINE/PubMed and EMBASE databases for articles published between January 1, 1990 and December 31, 2008. Each study was independently assessed by two reviewers with expertise in the field of oral oncology.
resultsThirty-nine studies assessed pain in the head and neck region. The measure was commonly embedded in quality of life studies. Most of these studies described pain in head and neck cancer (HNC) patients, which therefore became the focus of the report. Pain is common in patients with HNC and is reported by approximately half of patients prior to cancer therapy, 81% during therapy, 70% at the end of therapy, and by 36% at 6 months after treatment. Pain is experienced beyond the 6-month period by approximately one third of patients and is typically more severe than pre-treatment cancer-induced pain.
conclusionsThis systematic review identified the presence of pain before cancer therapy, likely attributable to the cancer; an increase in pain during therapy and the common persistence of pain following cancer treatment. Continuing research should use validated tools to prospectively assess orofacial pain, its causes and pathophysiology, and its effect on quality of life and economic impact. Clinical trials of pain management in this setting are also warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.